{"id":"W3027935303","doi":"10.18632/aging.103211","title":"Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Fudan University; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Alzheimer's Disease Neuroimaging Initiative; Neurogranin; Neurodegeneration; Internal medicine; Cognitive decline; Biomarker; Medicine; Alzheimer's disease; Atrophy; Hazard ratio; Oncology; Psychology; Cohort; Dementia; Endocrinology; Disease; Confidence interval; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006642463,0.000358062,0.0003001965,0.0009705307,0.0003291903,0.0005491789,0.0002402426,0.000304334,0.0004464122],"category_scores_gemma":[0.002202624,0.0001666132,0.0001850845,0.0005250313,0.0003997746,0.0002725914,0.0003681784,0.0003192581,0.00008430611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004001626,"about_ca_system_score_gemma":0.0002066925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004600877,"about_ca_topic_score_gemma":0.004391077,"domain_scores_codex":[0.9997731,0.00005557192,0.00003166471,0.00004687486,0.00006102322,0.00003170357],"domain_scores_gemma":[0.999079,0.0001892937,0.0004142231,0.00006951863,0.0001067326,0.0001412255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005161329,0.00005096352,0.995299,0.00001340463,0.00007800435,0.0001739871,0.00010687,0.00007143134,0.001049434,0.00001821446,0.0000551878,0.002567344],"study_design_scores_gemma":[0.000004809886,0.00005934834,0.9994049,0.000002341913,0.00001349553,0.0001908444,0.00003954952,0.00008272874,0.0001061896,0.00004361278,0.00005016617,0.000001988071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993599,0.0003576992,0.00003330133,0.00001551257,0.00000347678,0.000002080619,0.00005448233,0.000002310186,0.0001711959],"genre_scores_gemma":[0.9996785,0.0000924927,0.00006642308,0.00000800874,0.000004256936,0.000001775166,0.00007591586,8.064241e-7,0.00007180622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004600877,"threshold_uncertainty_score":0.00914818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03526987243177018,"score_gpt":0.2954592716641818,"score_spread":0.2601893992324117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}