{"id":"W3027935303","doi":"10.18632/aging.103211","title":"Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Fudan University; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Alzheimer's Disease Neuroimaging Initiative; Neurogranin; Neurodegeneration; Internal medicine; Cognitive decline; Biomarker; Medicine; Alzheimer's disease; Atrophy; Hazard ratio; Oncology; Psychology; Cohort; Dementia; Endocrinology; Disease; Confidence interval; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033148,0.00005465047,0.00009051905,0.00004952789,0.00002590345,0.00001617098,0.00001533238,0.00001288933,0.00003836301],"category_scores_gemma":[0.00007569639,0.00004948211,0.00001481531,0.0001574973,0.00001697174,0.00009770348,0.00001515491,0.00007733353,0.000002826006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001012691,"about_ca_system_score_gemma":0.00003842359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001097641,"about_ca_topic_score_gemma":0.000005868194,"domain_scores_codex":[0.9993533,0.0000505819,0.0001077143,0.0001420702,0.0002342496,0.0001120315],"domain_scores_gemma":[0.9997202,0.00002287363,0.00004225757,0.00003486189,0.00008407234,0.00009574019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002400815,0.00006009276,0.9534482,0.00005267977,0.00003541552,0.00003545636,0.0001441256,0.00000596272,0.03929077,0.0000179027,0.00006335622,0.00660596],"study_design_scores_gemma":[0.001600125,0.0003670278,0.9778694,0.00006544778,0.0001803124,0.00000223027,0.00004347288,0.002158437,0.01760012,0.00001261112,0.0000543426,0.00004646649],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937043,0.0001317975,0.0003453409,0.005207042,0.00001014544,0.000265211,0.000006367168,0.00001457775,0.0003151888],"genre_scores_gemma":[0.9989908,0.00001975332,0.0000924789,0.0007848304,0.00004245992,0.00001178747,0.00002869811,0.000007715,0.00002142427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02442121,"threshold_uncertainty_score":0.2017822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03526987243177018,"score_gpt":0.2954592716641818,"score_spread":0.2601893992324117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}