{"id":"W3027936000","doi":"10.1101/2020.05.22.20106062","title":"Comparing rapid micro-induction and standard induction of buprenorphine/naloxone for treatment of opioid use disorder: Protocol for an open-label, parallel-group, superiority, randomized controlled trial","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Provincial Health Services Authority; Vancouver General Hospital; BC Mental Health & Substance Use Services; University of British Columbia","funders":"","keywords":"Buprenorphine; (+)-Naloxone; Opioid use disorder; Medicine; Randomized controlled trial; Anesthesia; Opioid; Craving; Addiction; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03844376,0.008283713,0.01455353,0.002643141,0.003414432,0.005597524,0.004851304,0.009418922,0.05521769],"category_scores_gemma":[0.04209631,0.00346317,0.007248637,0.003304035,0.00582354,0.005441984,0.002279784,0.01001058,0.0101122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00643114,"about_ca_system_score_gemma":0.01496972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002339746,"about_ca_topic_score_gemma":0.004470262,"domain_scores_codex":[0.9694184,0.0182665,0.003065107,0.002517816,0.003800698,0.002931509],"domain_scores_gemma":[0.980478,0.006421744,0.004405568,0.002379236,0.003858893,0.002456591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9618877,0.009000161,0.0003151277,0.009574807,0.001815674,0.0001107611,0.0002080999,0.001178489,0.001023317,0.001716328,0.00476199,0.008407657],"study_design_scores_gemma":[0.9760129,0.01496803,0.0004544065,0.0008039663,0.0004341238,0.00002420364,0.00004418701,0.0009385828,0.0002705018,0.0008906355,0.005116012,0.00004254675],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00291819,0.000267163,0.0008987047,0.0002090094,0.0004441412,0.9939558,0.0005914656,0.0001053463,0.0006102153],"genre_scores_gemma":[0.003691526,0.000172086,0.002238142,0.0002412327,0.00009294897,0.9929248,0.0001430101,0.00001005752,0.0004862343],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05521769,"threshold_uncertainty_score":0.2033125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09610542101202353,"score_gpt":0.3642196248686653,"score_spread":0.2681142038566418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}