{"id":"W3027936000","doi":"10.1101/2020.05.22.20106062","title":"Comparing rapid micro-induction and standard induction of buprenorphine/naloxone for treatment of opioid use disorder: Protocol for an open-label, parallel-group, superiority, randomized controlled trial","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Provincial Health Services Authority; Vancouver General Hospital; BC Mental Health & Substance Use Services; University of British Columbia","funders":"","keywords":"Buprenorphine; (+)-Naloxone; Opioid use disorder; Medicine; Randomized controlled trial; Anesthesia; Opioid; Craving; Addiction; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001165278,0.0008313744,0.006747417,0.0003076363,0.0001580352,0.0001453903,0.0002942754,0.0004461953,0.00002403102],"category_scores_gemma":[0.0006368608,0.0006196861,0.0006530468,0.00014999,0.0002673902,0.0002629335,0.0002836163,0.0002228593,4.199251e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426814,"about_ca_system_score_gemma":0.0005640569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008254284,"about_ca_topic_score_gemma":0.0001332212,"domain_scores_codex":[0.9952022,0.0005523321,0.002204563,0.001164563,0.0004753521,0.0004009943],"domain_scores_gemma":[0.9962141,0.000629087,0.001497398,0.0008386628,0.0005618521,0.0002588865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9646748,0.00735451,0.004562082,0.002670573,0.003232711,0.000002621329,0.001485771,0.0000279582,0.01329951,0.0001400506,0.00003391653,0.002515455],"study_design_scores_gemma":[0.9612145,0.02382604,0.0009438389,0.000572561,0.00402279,0.000006479864,0.0002135741,0.001731513,0.004854736,0.0008746217,0.001305194,0.0004341381],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5726001,0.0003061717,0.003273378,0.0003694369,0.0003895528,0.4227352,0.0002587359,0.00005515655,0.00001226496],"genre_scores_gemma":[0.2725317,0.0004692474,0.03086347,0.00001649307,0.0004177802,0.6943841,0.00112698,0.0001283781,0.00006177108],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.3000683,"threshold_uncertainty_score":0.9996254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09610542101202353,"score_gpt":0.3642196248686653,"score_spread":0.2681142038566418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}