{"id":"W3027987756","doi":"10.1016/j.cell.2020.04.047","title":"Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Structural Genomics Consortium; Ontario Institute for Cancer Research; Hospital for Sick Children; Université de Montréal; McGill University; McGill University Health Centre; University of Calgary; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Institute for Research in Immunology and Cancer; University of British Columbia","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Brain Tumour Research; Canadian Institutes of Health Research; Terry Fox Research Institute; Brain Tumour Charity; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Hospital for Sick Children; Genome British Columbia; Ontario Genomics Institute; Government of Canada; Janssen Pharmaceuticals; Canadian Cancer Society; Bear Necessities Pediatric Cancer Foundation; National Institute of Neurological Disorders and Stroke; Stand Up To Cancer Canada; Government of Ontario; Baylor College of Medicine; Ontario Research Foundation; Worldwide Cancer Research; Mitacs; Ontario Institute for Cancer Research; Cancer Research UK; Wellcome Trust; Merck KGaA; Genome Canada; Takeda Pharmaceuticals U.S.A.; Meso Scale Diagnostics; V Foundation for Cancer Research; Pfizer; Innovative Medicines Initiative; Pediatric Brain Tumor Foundation; Novartis; University of Toronto; Alex's Lemonade Stand Foundation for Childhood Cancer; Stand Up To Cancer; Entertainment Industry Foundation; Boehringer Ingelheim; American Association for Cancer Research; Children's Brain Tumor Foundation; Swifty Foundation; Children's Cancer Research Fund; Cancer Prevention and Research Institute of Texas","keywords":"Biology; Epigenome; Ependymoma; Medulloblastoma; Epigenetics; Histone; Cancer research; Acetylation; Histone H3; Cell biology; DNA methylation; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008765608,0.0002585792,0.000255175,0.0002825489,0.0001644369,0.0002993282,0.0002864723,0.0002979303,0.001280302],"category_scores_gemma":[0.0002086104,0.0001289711,0.0001410737,0.0001609434,0.0002749352,0.0001530473,0.0003378813,0.000520819,0.0002297138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000322375,"about_ca_system_score_gemma":0.0001565513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004647399,"about_ca_topic_score_gemma":0.0008109362,"domain_scores_codex":[0.9999118,0.00001224339,0.000009044408,0.00001842713,0.00002521731,0.00002321336],"domain_scores_gemma":[0.9998783,0.00003434869,0.00003349939,0.00001670217,0.000009505079,0.00002763266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003107668,0.00003689425,0.002328624,0.00002789905,0.00001120339,0.004337899,0.00003968172,0.0003184691,0.9880827,0.0008787639,0.0001232351,0.003503827],"study_design_scores_gemma":[0.00002219884,0.0002201411,0.03023626,0.000006941976,0.00002992767,0.006885744,0.0001269838,0.001663406,0.9566887,0.0005333594,0.003574015,0.00001227784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962741,0.0003058216,0.001864331,0.0000859567,0.00001915816,0.000009206083,0.0002782435,0.00008020523,0.001083024],"genre_scores_gemma":[0.9978051,0.0002289998,0.0004999741,0.00002117337,0.000006378442,0.00001072027,0.0002323537,0.00001801821,0.001177224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280302,"threshold_uncertainty_score":0.004283071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819502315257725,"score_gpt":0.2201989243419105,"score_spread":0.2103794220266528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}