{"id":"W3027987756","doi":"10.1016/j.cell.2020.04.047","title":"Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Structural Genomics Consortium; Ontario Institute for Cancer Research; Hospital for Sick Children; Université de Montréal; McGill University; McGill University Health Centre; University of Calgary; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Institute for Research in Immunology and Cancer; University of British Columbia","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Brain Tumour Research; Canadian Institutes of Health Research; Terry Fox Research Institute; Brain Tumour Charity; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Hospital for Sick Children; Genome British Columbia; Ontario Genomics Institute; Government of Canada; Janssen Pharmaceuticals; Canadian Cancer Society; Bear Necessities Pediatric Cancer Foundation; National Institute of Neurological Disorders and Stroke; Stand Up To Cancer Canada; Government of Ontario; Baylor College of Medicine; Ontario Research Foundation; Worldwide Cancer Research; Mitacs; Ontario Institute for Cancer Research; Cancer Research UK; Wellcome Trust; Merck KGaA; Genome Canada; Takeda Pharmaceuticals U.S.A.; Meso Scale Diagnostics; V Foundation for Cancer Research; Pfizer; Innovative Medicines Initiative; Pediatric Brain Tumor Foundation; Novartis; University of Toronto; Alex's Lemonade Stand Foundation for Childhood Cancer; Stand Up To Cancer; Entertainment Industry Foundation; Boehringer Ingelheim; American Association for Cancer Research; Children's Brain Tumor Foundation; Swifty Foundation; Children's Cancer Research Fund; Cancer Prevention and Research Institute of Texas","keywords":"Biology; Epigenome; Ependymoma; Medulloblastoma; Epigenetics; Histone; Cancer research; Acetylation; Histone H3; Cell biology; DNA methylation; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006620483,0.00006876921,0.00008390716,0.00001003707,0.00003839668,0.000006597284,0.0001388024,0.00006863038,0.00003701712],"category_scores_gemma":[0.00003644261,0.000053652,0.00007699073,0.00008108126,0.0000429691,0.00000178913,0.00008165017,0.00004093233,0.000008099551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001439625,"about_ca_system_score_gemma":0.00002846541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006041127,"about_ca_topic_score_gemma":0.00000262928,"domain_scores_codex":[0.999483,0.00004831085,0.0001410487,0.0001513016,0.00008797787,0.00008828501],"domain_scores_gemma":[0.9996111,0.000006156975,0.00009266856,0.0002067021,0.00004384917,0.00003951979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009078716,0.00001173596,0.002793127,0.00001046904,0.000006504616,1.826319e-7,0.0001258293,0.0003037387,0.9960818,0.0000681218,0.00007866574,0.0005107693],"study_design_scores_gemma":[0.0001498033,0.00004764003,0.058649,0.000001544573,0.00001228557,2.525724e-7,0.00001726938,0.00010142,0.9089222,0.0001227294,0.03191566,0.00006019342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915641,0.00236753,0.0009424689,0.0002087043,0.00008838129,0.0001061658,0.000009452228,0.000004035377,0.004709159],"genre_scores_gemma":[0.9988924,0.0001068726,0.0003349538,0.00008597434,0.0001587589,0.000002720633,0.00002901683,0.0000104833,0.0003788761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08715957,"threshold_uncertainty_score":0.2187865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819502315257725,"score_gpt":0.2201989243419105,"score_spread":0.2103794220266528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}