{"id":"W3028006966","doi":"10.1136/bmjebm-2020-111386","title":"Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances","year":2020,"lang":"en","type":"article","venue":"BMJ evidence-based medicine","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton; Impact","funders":"","keywords":"Medicine; Thrombolysis; Stroke (engine); Modified Rankin Scale; Ischaemic stroke; Clinical trial; Placebo; Internal medicine; Physical therapy; Randomized controlled trial; Tissue plasminogen activator; Ischemic stroke; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":["metaresearch"],"domain":"methods","study_design":"meta_analysis","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"medium","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00170931,0.0007210145,0.001963613,0.0004357458,0.0001182858,0.00003132044,0.0004434291,0.0002034978,0.001395633],"category_scores_gemma":[0.00379376,0.000482986,0.0004926598,0.001315096,0.0004754497,0.0003194563,0.0001038232,0.0004788383,0.00005300624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220967,"about_ca_system_score_gemma":0.0005975784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291727,"about_ca_topic_score_gemma":0.00003554003,"domain_scores_codex":[0.9945742,0.000208488,0.001295673,0.001284295,0.001825213,0.0008121161],"domain_scores_gemma":[0.9952592,0.001379615,0.0006732777,0.001203688,0.0006052031,0.0008790572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4644588,0.0005015442,0.02318093,0.001756624,0.00633928,0.001953696,0.000753071,0.0003550365,0.01611804,0.00001853504,0.4743387,0.01022572],"study_design_scores_gemma":[0.5757156,0.06431678,0.01045601,0.02357329,0.1086551,0.0002437822,0.005985648,0.06112333,0.05237218,0.00002239158,0.0937123,0.003823573],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4838958,0.006351255,0.1616375,0.3323441,0.0008662692,0.01275979,0.0003877984,0.0007093294,0.001048106],"genre_scores_gemma":[0.9359354,0.0008814654,0.02016404,0.03276777,0.005615483,0.002276519,0.0005951154,0.0001572986,0.001606913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4520396,"threshold_uncertainty_score":0.9997622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06341808429054929,"score_gpt":0.3372272680659038,"score_spread":0.2738091837753545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}