{"id":"W3028042488","doi":"10.1016/j.eururo.2020.04.058","title":"Activating AKT1 and PIK3CA Mutations in Metastatic Castration-Resistant Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Hôpital Saint-Luc; Juravinski Cancer Centre; University of Calgary; BC Cancer Agency; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"AKT1; Prostate cancer; PTEN; Cancer research; Medicine; Mutation; Germline mutation; Cancer; Internal medicine; Oncology; PI3K/AKT/mTOR pathway; Biology; Gene; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331034,0.00009628573,0.0001625049,0.00007038365,0.00006122541,0.00001674968,0.00003818977,0.00001351764,0.0001011525],"category_scores_gemma":[0.0001304981,0.00007783374,0.00001952046,0.0001992475,0.00009302657,0.00006024083,0.00003774836,0.0001960128,0.00003008128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003115809,"about_ca_system_score_gemma":0.0001127968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006337344,"about_ca_topic_score_gemma":0.00004656619,"domain_scores_codex":[0.999089,0.0001666127,0.0001863673,0.0002413317,0.00009890094,0.0002177625],"domain_scores_gemma":[0.9996324,0.00007169783,0.00004696439,0.0000766258,0.00004170375,0.0001306318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009002497,0.000669589,0.2410004,0.001090138,0.0008347759,0.01202734,0.05199027,0.001343259,0.5301835,0.00119541,0.00323988,0.1474229],"study_design_scores_gemma":[0.01515132,0.003840159,0.9302691,0.0001130801,0.0002701587,0.000146309,0.002210921,0.004309711,0.00595788,0.0002440543,0.03701556,0.0004717696],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732965,0.001222707,0.0000240494,0.01998493,0.00003142246,0.0004198631,0.00002317927,0.00003748332,0.004959904],"genre_scores_gemma":[0.9977024,0.0001856478,0.0003526502,0.001290415,0.00006419811,0.00002872023,0.00003681104,0.00002343118,0.0003157646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6892686,"threshold_uncertainty_score":0.3173968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05629279256817002,"score_gpt":0.3327251990805374,"score_spread":0.2764324065123674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}