{"id":"W3028061161","doi":"10.1016/j.eplepsyres.2020.106369","title":"Effect of lifetime antiepileptic drug treatment history on efficacy and tolerability of adjunctive brivaracetam in adults with focal seizures: Post-hoc analysis of a randomized, placebo-controlled trial","year":2020,"lang":"en","type":"article","venue":"Epilepsy Research","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"UCB Pharma","keywords":"Tolerability; Medicine; Epilepsy; Adjunctive treatment; Placebo; Post-hoc analysis; Concomitant; Anesthesia; Randomized controlled trial; Internal medicine; Adverse effect; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005911186,0.0004265876,0.005163477,0.001364817,0.00005696197,0.000009212254,0.0002076024,0.0001628115,0.0002774712],"category_scores_gemma":[0.005531462,0.000256311,0.0008871099,0.001462631,0.001326627,0.00007343696,0.00009934165,0.0006199838,0.00000800584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006259832,"about_ca_system_score_gemma":0.0008574409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592178,"about_ca_topic_score_gemma":0.0002086479,"domain_scores_codex":[0.9898164,0.005458977,0.001367641,0.0008810876,0.00182812,0.0006477734],"domain_scores_gemma":[0.9838206,0.01376268,0.0004015253,0.0007379107,0.0007189672,0.0005583323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9567863,0.004053538,0.02227566,0.0007748291,0.006779679,0.0001890279,0.00449718,0.0001130358,0.000330472,0.00003284902,0.00009768936,0.004069771],"study_design_scores_gemma":[0.8685941,0.1076689,0.01436553,0.0005341427,0.002408113,0.000003245169,0.000244833,0.004151377,0.001865632,0.000004360111,0.00001316184,0.0001465609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812821,0.002121204,0.0000063977,0.0007037836,0.00003253539,0.01483605,0.00007449483,0.00002080506,0.0009226754],"genre_scores_gemma":[0.9978457,0.0005504793,0.00008614533,0.00002404212,0.00007300345,0.001107878,0.00009047566,0.00003551511,0.0001867753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1036154,"threshold_uncertainty_score":0.9999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162126660327237,"score_gpt":0.3290013293151761,"score_spread":0.3073800627119037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}