{"id":"W3028134516","doi":"10.1096/fj.202000463r","title":"Bone marrow‐derived mitochondrial DNA has limited capacity for inter‐tissue transfer in vivo","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Children’s Health Research Institute; London Health Sciences Centre; McMaster University","funders":"McMaster University; Health Research; Giant","keywords":"Mitochondrial DNA; Bone marrow; Microvesicles; Biology; Skeletal muscle; Exosome; Mitochondrion; Connective tissue; Cell biology; Molecular biology; Pathology; Immunology; Genetics; Anatomy; Medicine; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001008088,0.0002590528,0.0004594543,0.0004183071,0.0002292978,0.0007408561,0.0004223126,0.0006147458,0.003111899],"category_scores_gemma":[0.0007367266,0.0002153394,0.0001979763,0.0001846729,0.000309042,0.0005139609,0.0004302781,0.0008894645,0.001707887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003030058,"about_ca_system_score_gemma":0.0002891898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005999883,"about_ca_topic_score_gemma":0.0005986716,"domain_scores_codex":[0.9994305,0.0001530338,0.0000420677,0.0001443365,0.0001660031,0.00006410832],"domain_scores_gemma":[0.9993568,0.0002163063,0.00009276252,0.000144875,0.00009433589,0.00009488646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002427991,0.00008760788,0.0007927208,0.0001552809,0.00002909112,0.0001207196,0.0001019914,0.000173723,0.987246,0.0007279519,0.0002421576,0.01007992],"study_design_scores_gemma":[0.00007363371,0.00197843,0.008963351,0.00007483281,0.00007628925,0.00178674,0.0002315204,0.003612466,0.9612225,0.0009286863,0.02103412,0.00001736895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479055,0.01131813,0.03347536,0.0004670811,0.0001120103,0.0001403455,0.0006705434,0.0004116025,0.00549951],"genre_scores_gemma":[0.9928722,0.001012707,0.00280467,0.00009143006,0.00001138351,0.00006368674,0.0006719684,0.00004609461,0.002425932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003111899,"threshold_uncertainty_score":0.01041037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0280760366696524,"score_gpt":0.2425309148285657,"score_spread":0.2144548781589133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}