{"id":"W3028174036","doi":"10.1016/j.chembiol.2020.05.005","title":"CRISPR Lights up In Situ Protein Evolution","year":2020,"lang":"en","type":"letter","venue":"Cell chemical biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"CRISPR; In situ; Fluorescent protein; Protein evolution; Biology; Computational biology; Cas9; Directed evolution; Cell biology; Genetics; Green fluorescent protein; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00004734189,0.0003549565,0.0003615042,0.00006525102,0.00002059906,0.00001066698,0.000364464,0.001553493,0.00002636353],"category_scores_gemma":[0.00007196965,0.0003485207,0.0001553918,0.0001039764,0.0001009555,0.00000115498,0.0002131444,0.0009847204,0.00007481054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004896357,"about_ca_system_score_gemma":0.00007409589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001452938,"about_ca_topic_score_gemma":0.000005047898,"domain_scores_codex":[0.9982682,0.00006275427,0.0003287962,0.0007681489,0.0000803459,0.0004917433],"domain_scores_gemma":[0.9994063,0.00001569895,0.00007935282,0.0003803728,0.00003822755,0.00008006864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001955875,0.00001203984,0.00002196673,0.00009880263,0.0000131249,0.00002593529,0.00001000758,0.000001621591,0.7590867,0.000007091979,0.2406126,0.00009049998],"study_design_scores_gemma":[0.0002368961,0.00007536412,0.000003849907,0.00001417316,0.000009479295,0.000005363896,0.00000293008,0.000008305055,0.5944005,0.0002198356,0.4047663,0.0002570484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4653201,0.0207246,0.02461542,0.4617354,0.003647058,0.003392701,0.0002930177,0.0003222952,0.01994934],"genre_scores_gemma":[0.9125627,0.0000860689,0.0006093283,0.07784197,0.004836944,0.0001271685,0.002434108,0.00008377807,0.001417901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4472426,"threshold_uncertainty_score":0.9998967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006856239047882237,"score_gpt":0.2606901867723469,"score_spread":0.2538339477244647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}