{"id":"W3028174036","doi":"10.1016/j.chembiol.2020.05.005","title":"CRISPR Lights up In Situ Protein Evolution","year":2020,"lang":"en","type":"letter","venue":"Cell chemical biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"CRISPR; In situ; Fluorescent protein; Protein evolution; Biology; Computational biology; Cas9; Directed evolution; Cell biology; Genetics; Green fluorescent protein; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003494504,0.0005901864,0.0005416113,0.0003663352,0.0016811,0.002948422,0.001016448,0.01716777,0.005566595],"category_scores_gemma":[0.007211303,0.0004618272,0.000637928,0.0002022395,0.003200885,0.002069938,0.001708943,0.01807211,0.002833913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002378739,"about_ca_system_score_gemma":0.001236142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001958387,"about_ca_topic_score_gemma":0.004235771,"domain_scores_codex":[0.9982424,0.0003180316,0.00006705985,0.0001847603,0.0009247991,0.0002629912],"domain_scores_gemma":[0.9961661,0.00243955,0.0001636733,0.0002071736,0.00041446,0.0006090727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919292,0.00005998138,0.0002598673,0.00009692027,0.00002917438,0.0009203142,0.00009571606,0.0002617102,0.006143929,0.03879561,0.9172379,0.03590696],"study_design_scores_gemma":[0.00009438986,0.00007858677,0.0003082835,0.00003981809,0.00001787589,0.0006128617,0.00006916611,0.0006276269,0.006773537,0.02497633,0.9663712,0.00003038833],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.002243309,0.01077879,0.007414078,0.8767477,0.07461871,0.00004202198,0.0001259074,0.0004249339,0.02760454],"genre_scores_gemma":[0.04929922,0.007847462,0.006224756,0.7829022,0.04604255,0.0001333937,0.0000993707,0.0001838744,0.1072671],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01716777,"threshold_uncertainty_score":0.0186221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006856239047882237,"score_gpt":0.2606901867723469,"score_spread":0.2538339477244647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}