{"id":"W3028245882","doi":"10.1038/s41598-020-65109-7","title":"SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Hillman Foundation; Susan G. Komen; Breast Cancer Research Foundation; University of Pittsburgh; McGill University","keywords":"Gene silencing; Biology; Oncogene; Signal transduction; Growth factor; Cancer research; Cell growth; Cell cycle; MAPK/ERK pathway; Gene; Cell biology; Insulin-like growth factor; Long non-coding RNA; Regulation of gene expression; Genetics; Receptor; Downregulation and upregulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006920764,0.0002668409,0.0001865007,0.0003737167,0.0003223357,0.0002636425,0.0002163655,0.0001970576,0.001426869],"category_scores_gemma":[0.0001069008,0.00009726787,0.0003161706,0.0002788818,0.0002589127,0.0001382906,0.0002542664,0.0002807618,0.0005824374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894499,"about_ca_system_score_gemma":0.0003159516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007532936,"about_ca_topic_score_gemma":0.001626893,"domain_scores_codex":[0.9999102,0.000009538001,0.000005791593,0.00001958419,0.00003912039,0.00001565003],"domain_scores_gemma":[0.9999036,0.00001651529,0.00003061468,0.000008214472,0.00002293218,0.00001822783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402339,0.0000155361,0.003037012,0.0001201894,0.00002922569,0.0008176588,0.00005335325,0.0001760606,0.9789349,0.001080728,0.0009238655,0.01467128],"study_design_scores_gemma":[0.00004070539,0.0003236401,0.05168583,0.00004304942,0.000109642,0.005170919,0.0001737959,0.005119842,0.8798028,0.001177901,0.0563079,0.00004402679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508104,0.010806,0.02147257,0.0006424877,0.0005222115,0.00006875108,0.002672968,0.001679285,0.01132546],"genre_scores_gemma":[0.9784065,0.002511674,0.007489289,0.0003964425,0.00007901704,0.00005972636,0.003212928,0.0001404013,0.007704104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426869,"threshold_uncertainty_score":0.004773378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771356977530088,"score_gpt":0.2692179503223773,"score_spread":0.2515043805470764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}