{"id":"W3028499637","doi":"10.1128/msystems.00204-20","title":"Overexpression of the Small RNA PA0805.1 in Pseudomonas aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance","year":2020,"lang":"en","type":"article","venue":"mSystems","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of British Columbia","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Pseudomonas aeruginosa; Biology; Tobramycin; Transcriptome; Gene; Virulence; Efflux; Microbiology; Small RNA; Swarming motility; Multiple drug resistance; Genetics; Gene expression; Quorum sensing; Drug resistance; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105745,0.0003644655,0.0001859344,0.0002307077,0.0001492101,0.00027558,0.0002014013,0.0003026734,0.0006391305],"category_scores_gemma":[0.0001470934,0.0001468334,0.0002163212,0.0001799472,0.0002335548,0.0001643568,0.0002132427,0.0005356917,0.0003235099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003627301,"about_ca_system_score_gemma":0.0002305665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007973566,"about_ca_topic_score_gemma":0.001089955,"domain_scores_codex":[0.9998274,0.00002259095,0.00001976444,0.00003573953,0.00006427645,0.00003021946],"domain_scores_gemma":[0.9999007,0.00002306446,0.00003457482,0.0000104917,0.00001087026,0.0000203258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001783831,0.00001033413,0.00006383315,0.00001042834,9.688513e-7,0.00001386243,0.000003650797,0.00001659164,0.9995309,0.00001828326,0.00001107401,0.0003022187],"study_design_scores_gemma":[0.000005269646,0.0001241073,0.004462839,0.000005837408,0.000009367062,0.0001256981,0.00002859793,0.0009044354,0.9930643,0.00003276558,0.001231456,0.000005326244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994696,0.0007171792,0.002839477,0.0001461474,0.00003621609,0.00002383234,0.0005852935,0.0001101712,0.000845808],"genre_scores_gemma":[0.9921514,0.0004498275,0.003614698,0.00009361785,0.000008424112,0.00003626735,0.001084671,0.00004074211,0.00252041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007973566,"threshold_uncertainty_score":0.002631783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582258569981156,"score_gpt":0.2287858066829405,"score_spread":0.2129632209831289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}