{"id":"W3028527300","doi":"10.1038/s41467-020-16317-2","title":"HOX13-dependent chromatin accessibility underlies the transition towards the digit development program","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Université de Montréal; Government of Canada; École Polytechnique Fédérale de Lausanne; Compute Canada","keywords":"Hox gene; Chromatin; Limb development; Ectopic expression; Biology; Transcription factor; Homeobox; ChIA-PET; Homeotic gene; Evolutionary biology; Genetics; Computational biology; Context (archaeology); Gene; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181584,0.0001261853,0.0001395219,0.0001487178,0.0001679369,0.000399594,0.0001667459,0.0002131986,0.002160789],"category_scores_gemma":[0.0001175858,0.0001477986,0.0001459945,0.0001246315,0.0003365395,0.000130106,0.0003407552,0.0003017563,0.000520972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464734,"about_ca_system_score_gemma":0.0002188192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000667498,"about_ca_topic_score_gemma":0.00156872,"domain_scores_codex":[0.9999081,0.000008359048,0.000005436604,0.00002979637,0.000022889,0.00002532062],"domain_scores_gemma":[0.9999048,0.00001643515,0.00002355969,0.00001168667,0.00001126636,0.00003221647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006548117,0.000006603344,0.001896304,0.00001689386,0.000002529053,0.00007028288,0.00001509586,0.000084937,0.9957949,0.0003903582,0.00002720955,0.001629398],"study_design_scores_gemma":[0.00001324793,0.00009838778,0.1857765,0.00001419138,0.00001305451,0.0007559918,0.00006529608,0.001627636,0.8076767,0.000492887,0.003456299,0.000009696496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855398,0.0007871503,0.00954664,0.00005538107,0.00001539917,0.0000187863,0.0004297396,0.0001169893,0.003490185],"genre_scores_gemma":[0.996035,0.0002423655,0.001266421,0.00002266461,0.00000379835,0.000009913775,0.0003159614,0.00001455912,0.002089316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002160789,"threshold_uncertainty_score":0.007228553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778700672011283,"score_gpt":0.2954437754871424,"score_spread":0.2676567687670296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}