{"id":"W3028550899","doi":"10.1016/s2213-8587(20)30114-5","title":"Flexible insulin therapy with a hybrid regimen of insulin degludec and continuous subcutaneous insulin infusion with pump suspension before exercise in physically active adults with type 1 diabetes (FIT Untethered): a single-centre, open-label, proof-of-concept, randomised crossover trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes Management and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University; LMC Diabetes & Endocrinology (Canada)","funders":"Boehringer Ingelheim; Gilead Sciences; Medtronic; Novo Nordisk; Merck; Janssen Pharmaceuticals; Bayer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Insulin pump; Insulin degludec; Insulin; Regimen; Type 1 diabetes; Diabetes mellitus; Type 2 diabetes; Hypoglycemia; Crossover study; Internal medicine; Physical therapy; Endocrinology; Insulin glargine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003277588,0.0004980442,0.002007177,0.0001847257,0.0000992182,0.00006985787,0.0006456095,0.000110567,0.00006830465],"category_scores_gemma":[0.0002303565,0.0002783659,0.00005992535,0.0008562401,0.00105181,0.000222825,0.0004316207,0.0006348183,0.000005504692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005863842,"about_ca_system_score_gemma":0.0002226964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006206556,"about_ca_topic_score_gemma":0.00006174808,"domain_scores_codex":[0.9964934,0.0003372289,0.0006158858,0.0007492212,0.0005347777,0.001269462],"domain_scores_gemma":[0.9976807,0.0005056474,0.0005469575,0.0006445918,0.0004374517,0.0001846386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.800268,0.002880137,0.01180469,0.0005348327,0.0009017548,0.0002553726,0.003140169,0.00007456487,0.01378652,0.00007161194,0.0001740165,0.1661084],"study_design_scores_gemma":[0.6401219,0.05415954,0.004338695,0.002701499,0.0004314053,0.00001171656,0.0006334113,0.001228865,0.2947578,0.0002800894,0.0007179393,0.0006170849],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988084,0.001938681,0.000003917444,0.001914082,0.00004651006,0.007424104,0.00003909698,0.00007453241,0.0004750343],"genre_scores_gemma":[0.9980201,0.0003785081,0.0003852185,0.0004853974,0.0001377682,0.0002392377,0.00007954917,0.00008515453,0.0001890808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2809713,"threshold_uncertainty_score":0.9999669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03800815549740619,"score_gpt":0.2829221855954858,"score_spread":0.2449140300980796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}