{"id":"W3028550899","doi":"10.1016/s2213-8587(20)30114-5","title":"Flexible insulin therapy with a hybrid regimen of insulin degludec and continuous subcutaneous insulin infusion with pump suspension before exercise in physically active adults with type 1 diabetes (FIT Untethered): a single-centre, open-label, proof-of-concept, randomised crossover trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes Management and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University; LMC Diabetes & Endocrinology (Canada)","funders":"Boehringer Ingelheim; Gilead Sciences; Medtronic; Novo Nordisk; Merck; Janssen Pharmaceuticals; Bayer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Insulin pump; Insulin degludec; Insulin; Regimen; Type 1 diabetes; Diabetes mellitus; Type 2 diabetes; Hypoglycemia; Crossover study; Internal medicine; Physical therapy; Endocrinology; Insulin glargine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00181607,0.00216582,0.005178421,0.0005813171,0.0004980384,0.00181457,0.001148753,0.002379534,0.006586604],"category_scores_gemma":[0.001609659,0.0009288308,0.003206805,0.0006319667,0.001778144,0.002084512,0.0008810192,0.003724144,0.001163995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007657091,"about_ca_system_score_gemma":0.0006522702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103309,"about_ca_topic_score_gemma":0.001338684,"domain_scores_codex":[0.9990741,0.000337896,0.00008383644,0.0002562813,0.00007480656,0.0001730641],"domain_scores_gemma":[0.9991801,0.0002265528,0.0001760427,0.0001055052,0.00004543453,0.0002663537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9843173,0.005740097,0.0002505087,0.0003908685,0.0007144031,0.00001737334,0.00003483252,0.0001327922,0.001056334,0.00005009997,0.0001301285,0.007165309],"study_design_scores_gemma":[0.9215311,0.07646959,0.001041974,0.00003695654,0.0003242576,0.00001634197,0.00002621288,0.0001748995,0.000145252,0.00007217654,0.0001455057,0.00001576089],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990399,0.004216756,0.0008633425,0.0003035532,0.0007761643,0.001866079,0.0005307984,0.00009773715,0.0009466183],"genre_scores_gemma":[0.9883999,0.002624549,0.002511671,0.0008314889,0.0006953462,0.002650494,0.0006774671,0.00002625172,0.001583006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006586604,"threshold_uncertainty_score":0.02203441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03800815549740619,"score_gpt":0.2829221855954858,"score_spread":0.2449140300980796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}