{"id":"W3028614809","doi":"10.1200/jco.2020.38.15_suppl.9502","title":"CCTG BR.34: A randomized trial of durvalumab and tremelimumab +/- platinum-based chemotherapy in patients with metastatic (Stage IV) squamous or nonsquamous non-small cell lung cancer (NSCLC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Humber River Regional Hospital; University of Saskatchewan; University of Alberta; Centre Hospitalier de l’Université de Montréal; Windsor Regional Hospital; University of Toronto; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; University of Ottawa","funders":"Canadian Cancer Society Research Institute","keywords":"Pemetrexed; Medicine; Durvalumab; Internal medicine; Gemcitabine; Lung cancer; Oncology; Chemotherapy; Tremelimumab; Clinical endpoint; Cancer; Randomized controlled trial; Pembrolizumab; Cisplatin; Immunotherapy; Ipilimumab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001598968,0.001699595,0.00229039,0.0004273924,0.0004744269,0.001005106,0.001269528,0.001706395,0.007484317],"category_scores_gemma":[0.001834339,0.000677755,0.001253604,0.0005043415,0.0009566771,0.0006628487,0.0005082163,0.003373632,0.001063274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001698763,"about_ca_system_score_gemma":0.002570422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007981369,"about_ca_topic_score_gemma":0.02528001,"domain_scores_codex":[0.9992034,0.0004786182,0.00003533755,0.00009740267,0.00005253293,0.0001327457],"domain_scores_gemma":[0.9989945,0.000174994,0.0002255713,0.00004475148,0.00005856721,0.0005016019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9826032,0.003735542,0.0006218779,0.0004307169,0.0004743057,0.00003939044,0.00003874301,0.0002128099,0.001677328,0.00009923347,0.001554911,0.00851194],"study_design_scores_gemma":[0.9660864,0.03120294,0.001321954,0.00002540359,0.0003230765,0.00002927357,0.00001391187,0.0002492164,0.0001234465,0.00005892886,0.0005566833,0.000008728723],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782149,0.004462133,0.0003898652,0.001319084,0.0007158717,0.007756062,0.002160469,0.0001521149,0.004829621],"genre_scores_gemma":[0.9824761,0.001821299,0.0013467,0.001780836,0.0004521868,0.005353532,0.002468898,0.00002652193,0.00427392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007981369,"threshold_uncertainty_score":0.02503753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04899802443508074,"score_gpt":0.4194738323229189,"score_spread":0.3704758078878382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}