{"id":"W3028663891","doi":"10.1007/s40262-020-00898-8","title":"Comparative Clinical Pharmacokinetics and Pharmacodynamics of HIV-1 Integrase Strand Transfer Inhibitors: An Updated Review","year":2020,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Dolutegravir; Raltegravir; Pharmacology; Elvitegravir; Pharmacokinetics; Pharmacodynamics; Integrase; Integrase inhibitor; Medicine; Virology; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001291584,0.0007686033,0.002107933,0.002173233,0.0001576586,0.001406294,0.00100867,0.001033679,0.003680463],"category_scores_gemma":[0.001941015,0.0003532836,0.001296049,0.002360784,0.0003205063,0.001430836,0.0004165531,0.001493853,0.001242203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005712362,"about_ca_system_score_gemma":0.001303002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111749,"about_ca_topic_score_gemma":0.001323467,"domain_scores_codex":[0.9995715,0.00009081466,0.0001062922,0.00007527005,0.00013319,0.00002287063],"domain_scores_gemma":[0.9988263,0.0006518207,0.0001773425,0.00002375198,0.0002820247,0.00003876755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002659322,0.00009586589,0.0003013994,0.0262064,0.0003258407,0.0001188009,0.00004523231,0.000289909,0.001079922,0.001171838,0.02393942,0.9461594],"study_design_scores_gemma":[0.0001891354,0.00052416,0.002957185,0.01493917,0.001835495,0.002290941,0.00009549853,0.0003893013,0.0010695,0.001607673,0.9740298,0.00007225614],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001983218,0.9988087,0.0001298326,0.0002207891,0.0001387907,0.000007788174,0.00004121394,0.000006720546,0.00044787],"genre_scores_gemma":[0.001097191,0.997739,0.0002600806,0.0002821802,0.000202862,0.00001271954,0.00009281642,0.000003207939,0.0003100204],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003680463,"threshold_uncertainty_score":0.01231241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1560651377284637,"score_gpt":0.4919753380905803,"score_spread":0.3359102003621166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}