{"id":"W3028710404","doi":"10.1002/advs.202000112","title":"MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling","year":2020,"lang":"en","type":"article","venue":"Advanced Science","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; National Natural Science Foundation of China","keywords":"Cetuximab; MLH1; Cancer research; Protein kinase B; PI3K/AKT/mTOR pathway; Gene knockdown; Colorectal cancer; Biology; Signal transduction; Medicine; Cancer; Internal medicine; Apoptosis; Cell biology; DNA mismatch repair; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007412047,0.0002108206,0.0001492307,0.0002083309,0.0001150955,0.0001900368,0.0001007835,0.0002169361,0.001647474],"category_scores_gemma":[0.00007803822,0.0001419449,0.0001486842,0.0001097895,0.0001505932,0.00009735928,0.0001085909,0.0004859121,0.000269188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003849636,"about_ca_system_score_gemma":0.000176143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005869385,"about_ca_topic_score_gemma":0.0009931098,"domain_scores_codex":[0.9999212,0.00001283167,0.000006932511,0.00001214811,0.0000204068,0.00002654223],"domain_scores_gemma":[0.9999384,0.00001205357,0.00001747957,0.00000745167,0.000003712972,0.00002087681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000278145,0.0000697144,0.0004842504,0.00002404667,0.000005403831,0.00007030259,0.000006034541,0.00009249919,0.9978874,0.00006479,0.00007631128,0.0009411166],"study_design_scores_gemma":[0.00007742198,0.0008814355,0.01313958,0.000005249844,0.00001591889,0.000522744,0.00002682246,0.001890205,0.9818881,0.00005986434,0.001488981,0.000003701357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984592,0.0004957894,0.0002919259,0.0000785013,0.00001369908,0.00001294973,0.0001649888,0.00003892832,0.0004439287],"genre_scores_gemma":[0.9982986,0.00022406,0.0002833989,0.00002894191,0.000002915776,0.00001352198,0.0001913154,0.00000465763,0.0009524899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647474,"threshold_uncertainty_score":0.005511343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02898723340171051,"score_gpt":0.3143922622046387,"score_spread":0.2854050288029282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}