{"id":"W3028710404","doi":"10.1002/advs.202000112","title":"MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling","year":2020,"lang":"en","type":"article","venue":"Advanced Science","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; National Natural Science Foundation of China","keywords":"Cetuximab; MLH1; Cancer research; Protein kinase B; PI3K/AKT/mTOR pathway; Gene knockdown; Colorectal cancer; Biology; Signal transduction; Medicine; Cancer; Internal medicine; Apoptosis; Cell biology; DNA mismatch repair; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003660573,0.0002254201,0.0003613102,0.0001548349,0.0002044533,0.00003876171,0.0005151571,0.0000779671,0.000186518],"category_scores_gemma":[0.000674477,0.0002100049,0.00005189206,0.002661196,0.0006347382,0.0003537583,0.0001351104,0.0003824434,0.00003009671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005002208,"about_ca_system_score_gemma":0.0008249143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006953857,"about_ca_topic_score_gemma":0.0002795448,"domain_scores_codex":[0.9971277,0.0000340192,0.0003876129,0.0008745174,0.0008839032,0.0006922478],"domain_scores_gemma":[0.9988738,0.0001026163,0.000145721,0.0003290872,0.0002252912,0.0003235333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000278225,0.00006151769,0.006342183,0.00008295468,0.000002806678,0.00003707247,0.001567996,0.001707754,0.9795608,0.0000911914,0.00005187969,0.01021561],"study_design_scores_gemma":[0.002532779,0.0008830965,0.02505943,0.0004591403,0.0000317792,0.00001212196,0.0006780102,0.001260916,0.9638987,0.0009915192,0.00358615,0.0006063917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884676,0.003079844,0.0007121186,0.002547871,0.0004526437,0.0005187368,0.000006827533,0.0000876557,0.004126711],"genre_scores_gemma":[0.9871169,0.0000882067,0.01039773,0.002042066,0.00008880604,0.00008802064,0.000001221525,0.00002341532,0.0001536063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01871724,"threshold_uncertainty_score":0.8563751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02898723340171051,"score_gpt":0.3143922622046387,"score_spread":0.2854050288029282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}