{"id":"W3028754062","doi":"10.1200/jco.2020.38.15_suppl.9582","title":"Final analysis of KEYNOTE-189: Pemetrexed-platinum chemotherapy (chemo) with or without pembrolizumab (pembro) in patients (pts) with previously untreated metastatic nonsquamous non-small cell lung cancer (NSCLC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Hôpital Charles-Le Moyne","funders":"","keywords":"Medicine; Pemetrexed; Lung cancer; Placebo; Internal medicine; Clinical endpoint; Oncology; Carboplatin; Cisplatin; Randomization; Progression-free survival; Chemotherapy; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007164369,0.001617556,0.002524132,0.0005125045,0.000448338,0.001665541,0.001687825,0.001588559,0.0104458],"category_scores_gemma":[0.005792413,0.0007816305,0.006277364,0.0006094998,0.0006516799,0.0008937211,0.0009835103,0.002339774,0.001695505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001537725,"about_ca_system_score_gemma":0.002135355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009734993,"about_ca_topic_score_gemma":0.002826213,"domain_scores_codex":[0.9966124,0.002045628,0.0002706,0.0004285805,0.0003501437,0.0002926274],"domain_scores_gemma":[0.9976388,0.0006820373,0.0004827153,0.0003799847,0.0003414087,0.0004750376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9442913,0.004155206,0.003209576,0.0014018,0.007835586,0.0001402705,0.00008462674,0.001342292,0.007799278,0.0002870946,0.006398348,0.02305458],"study_design_scores_gemma":[0.7673339,0.1750136,0.02492394,0.0001361996,0.01418236,0.0003009908,0.0000699392,0.0009465512,0.004089725,0.0004195852,0.01251985,0.00006338517],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9012862,0.008615376,0.006442086,0.001815062,0.0009756106,0.03012036,0.03804668,0.0005343527,0.01216422],"genre_scores_gemma":[0.9388249,0.00190908,0.00731004,0.002245322,0.0003041865,0.01091781,0.03277862,0.0001742227,0.005535884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0104458,"threshold_uncertainty_score":0.0378893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05799861924725461,"score_gpt":0.4282136198917117,"score_spread":0.3702150006444571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}