{"id":"W3028790470","doi":"10.1101/2020.05.29.123810","title":"Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hamilton Health Sciences Foundation","keywords":"Viral shedding; Infectious dose; Viral pneumonia; Outbreak; Medicine; Virology; Coronavirus; Pneumonia; Respiratory system; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Respiratory tract; Coronavirus disease 2019 (COVID-19); Immunology; Disease; Virus; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003061116,0.0005258794,0.0007447453,0.0008033728,0.0000981343,0.0001238571,0.0005894225,0.0004640007,0.000002181231],"category_scores_gemma":[0.001832122,0.0004244533,0.0001413354,0.00162564,0.0000871179,0.0001657168,0.0006429399,0.001532069,0.00006864926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007766103,"about_ca_system_score_gemma":0.001715556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009837507,"about_ca_topic_score_gemma":0.0001894255,"domain_scores_codex":[0.9955437,0.0006604075,0.0006627396,0.001254166,0.001313375,0.0005656221],"domain_scores_gemma":[0.9969847,0.0001692678,0.0002645741,0.001711596,0.0007473918,0.0001225004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00996115,0.0002829595,0.002551545,0.001070652,0.00008744585,0.000178948,0.0003230633,0.0003549626,0.9850497,0.00004728848,0.00007989717,0.00001241502],"study_design_scores_gemma":[0.001334224,0.00242137,0.04794234,0.003660477,0.0001334052,2.522206e-7,0.00002014028,0.004048277,0.9372692,0.000008737354,0.002531881,0.0006297245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819373,0.0002690471,0.007151103,0.005351366,0.0001826802,0.00483157,0.00002448763,0.0002345322,0.00001795189],"genre_scores_gemma":[0.98828,0.00003119626,0.001113902,0.008574843,0.0002134104,0.001661682,4.66123e-8,0.0001241062,8.147325e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0477805,"threshold_uncertainty_score":0.9998207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042116192524389,"score_gpt":0.3429344169277458,"score_spread":0.2387227976753069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}