{"id":"W3028821717","doi":"10.1200/jco.2020.38.15_suppl.e19410","title":"Impact of value frameworks on the magnitude of clinical benefit: Evaluating a decade of randomized trials for systemic therapy in solid malignancies.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Economic and Financial Impacts of Cancer","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; Baker Hughes (Canada); Alberta Health Services; University of Calgary","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Progression-free survival; Exact test; Randomized controlled trial; Quality of life (healthcare); Clinical trial; Cancer; Oncology; Statistical significance; Surrogate endpoint; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3488029,0.0008900855,0.002734945,0.002313695,0.0005354308,0.005160676,0.001650613,0.002545075,0.002853952],"category_scores_gemma":[0.3902808,0.0006574203,0.009009752,0.003602528,0.002647588,0.005037385,0.003143577,0.002837711,0.0002447727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003841485,"about_ca_system_score_gemma":0.005135865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008970145,"about_ca_topic_score_gemma":0.001713157,"domain_scores_codex":[0.5971454,0.3529653,0.02224038,0.006113432,0.01915838,0.002377104],"domain_scores_gemma":[0.4473489,0.4299091,0.09353472,0.01343325,0.01099596,0.004778127],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1758383,0.001060105,0.2605905,0.02567058,0.1355962,0.0001456733,0.0008041356,0.007472292,0.001246031,0.01918535,0.008818211,0.3635727],"study_design_scores_gemma":[0.1082288,0.07870861,0.4312842,0.04572412,0.1459102,0.0008341166,0.001943382,0.02957036,0.004728529,0.04242117,0.1100156,0.0006308061],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3769257,0.526957,0.0280756,0.03466279,0.004222762,0.009523734,0.004744026,0.0002000562,0.01468836],"genre_scores_gemma":[0.9684231,0.009860323,0.01192602,0.005055054,0.0006779428,0.002731789,0.000848876,0.0000439629,0.0004328733],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9991099,"threshold_uncertainty_score":0.803042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4512664638247991,"score_gpt":0.5333081009055094,"score_spread":0.08204163708071033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}