{"id":"W3028822324","doi":"10.1007/s12035-020-01942-1","title":"Trehalose Inhibits Aβ Generation and Plaque Formation in Alzheimer’s Disease","year":2020,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Trehalose; Senile plaques; In vivo; In vitro; Alzheimer's disease; Western blot; Thioflavin; Genetically modified mouse; Amyloid (mycology); Biology; Transgene; Pathology; Biochemistry; Chemistry; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000280493,0.0001224821,0.0001646567,0.00007768003,0.00003220375,0.00001118084,0.00003319598,0.00005490033,0.00001800172],"category_scores_gemma":[0.0000514175,0.0001084446,0.00004420751,0.0001238765,0.00005171183,0.0001032565,0.00004740806,0.0001149079,0.00004280516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001461172,"about_ca_system_score_gemma":0.00004549287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001271339,"about_ca_topic_score_gemma":0.00000503775,"domain_scores_codex":[0.9991389,0.000130689,0.0001622453,0.0002753496,0.00008439036,0.0002084048],"domain_scores_gemma":[0.9994388,0.00001461974,0.00003172485,0.0001203205,0.0000293544,0.0003652039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00728962,0.002600426,0.1849524,0.0004622428,0.004412615,0.02407434,0.001716056,0.0002319748,0.7237455,0.003477611,0.004536316,0.04250085],"study_design_scores_gemma":[0.03252122,0.007302716,0.4756264,0.0002222059,0.003215355,0.0007068807,0.0001113881,0.05598081,0.4181522,0.0007644891,0.003887292,0.001509083],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880304,0.003770971,0.00008143818,0.007307204,0.00002286968,0.0006340182,0.0000227132,0.00003366731,0.00009665592],"genre_scores_gemma":[0.9954348,0.0001824621,0.00006761026,0.003786821,0.0000574742,0.00007004242,0.0003842904,0.00001556548,9.245746e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3055933,"threshold_uncertainty_score":0.4422244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04622393888078801,"score_gpt":0.295649139546461,"score_spread":0.249425200665673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}