{"id":"W3028822324","doi":"10.1007/s12035-020-01942-1","title":"Trehalose Inhibits Aβ Generation and Plaque Formation in Alzheimer’s Disease","year":2020,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Trehalose; Senile plaques; In vivo; In vitro; Alzheimer's disease; Western blot; Thioflavin; Genetically modified mouse; Amyloid (mycology); Biology; Transgene; Pathology; Biochemistry; Chemistry; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538504,0.0005272843,0.0004473973,0.0002610838,0.0001593753,0.0003077401,0.0003165814,0.0003555406,0.002217661],"category_scores_gemma":[0.0002747846,0.0001392776,0.0003979545,0.0001428516,0.0001973869,0.0003658452,0.0001946792,0.0008724071,0.0003875962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909744,"about_ca_system_score_gemma":0.0003774734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001638458,"about_ca_topic_score_gemma":0.00179224,"domain_scores_codex":[0.9999037,0.00002355292,0.000009238915,0.00001071991,0.00001754228,0.00003525857],"domain_scores_gemma":[0.9999224,0.00001118371,0.00001209686,0.00001070462,0.00001323291,0.00003042737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01985297,0.001544896,0.0003627788,0.0002715578,0.0001394765,0.0002281355,0.00004116215,0.0003530612,0.9506467,0.0003564617,0.0008145452,0.02538822],"study_design_scores_gemma":[0.001164358,0.01129906,0.007102706,0.00004772072,0.0001676831,0.0004446791,0.00006265566,0.001059685,0.9710995,0.0003811488,0.007145723,0.00002510067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880891,0.007116514,0.0009411732,0.0002804806,0.000183884,0.00004959235,0.0003652589,0.0001331833,0.00284087],"genre_scores_gemma":[0.9907566,0.004097636,0.0008330701,0.0001069077,0.00006708775,0.00003590246,0.0004977104,0.00002105374,0.003583923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002217661,"threshold_uncertainty_score":0.007418752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04622393888078801,"score_gpt":0.295649139546461,"score_spread":0.249425200665673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}