{"id":"W3028965142","doi":"10.1080/15548627.2020.1761659","title":"Using Reactome to build an autophagy mechanism knowledgebase","year":2020,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Human Genome Research Institute; European Bioinformatics Institute; Foundation for the National Institutes of Health","keywords":"Autophagy; Biology; Computational biology; PI3K/AKT/mTOR pathway; Cell biology; Sequestosome 1; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00280334,0.002880459,0.001800766,0.01077638,0.001499889,0.004756089,0.004113548,0.002294645,0.02673685],"category_scores_gemma":[0.008932431,0.00143799,0.004810812,0.005162958,0.0007088201,0.004349179,0.004537583,0.003295997,0.01462802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00268607,"about_ca_system_score_gemma":0.004987516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009190749,"about_ca_topic_score_gemma":0.01125657,"domain_scores_codex":[0.9983526,0.0002052098,0.0003499485,0.0005185866,0.0004723308,0.0001013531],"domain_scores_gemma":[0.9972858,0.001037769,0.0002642278,0.0005375308,0.0007197363,0.0001548133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001187591,0.0005853898,0.006587808,0.02658828,0.001745748,0.006361683,0.001701986,0.06344737,0.0312989,0.1183183,0.4410116,0.3011653],"study_design_scores_gemma":[0.0002077471,0.00008403636,0.001724141,0.00170224,0.0006261383,0.0009625921,0.0002935759,0.03767977,0.01656743,0.03976632,0.9002032,0.0001827699],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.006873812,0.003827467,0.3451726,0.001572743,0.001038051,0.001485236,0.5269014,0.08670072,0.02642806],"genre_scores_gemma":[0.01874914,0.003996638,0.2776469,0.0007145068,0.000121515,0.002194948,0.6850948,0.006023661,0.005457828],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02673685,"threshold_uncertainty_score":0.08944368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09045085359650998,"score_gpt":0.3660516334232336,"score_spread":0.2756007798267236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}