{"id":"W3028971888","doi":"10.1200/jco.2020.38.15_suppl.10023","title":"Time to central nervous system (CNS) metastases (mets) with atezolizumab (A) or placebo (P) combined with cobimetinib (C) + vemurafenib (V) in the phase III IMspire150 study.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Roche","keywords":"Medicine; Vemurafenib; Internal medicine; Gastroenterology; Magnetic resonance imaging; Placebo; Nuclear medicine; Pathology; Metastatic melanoma; Cancer; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001392839,0.0006046918,0.001090408,0.0001834255,0.0001370154,0.0004594642,0.0004460889,0.0005131916,0.002206916],"category_scores_gemma":[0.001019266,0.0002936236,0.001119597,0.0001717498,0.000316669,0.0003720245,0.000245446,0.001257989,0.0002932674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005297311,"about_ca_system_score_gemma":0.0007785985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004765168,"about_ca_topic_score_gemma":0.001672234,"domain_scores_codex":[0.9996183,0.0002018703,0.00002483254,0.00007043045,0.00003351451,0.00005113619],"domain_scores_gemma":[0.9994318,0.0001443985,0.0001785367,0.00003872806,0.00002419316,0.0001823332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9198089,0.007458865,0.01099797,0.0004363107,0.001889387,0.0001155167,0.00006011945,0.001441227,0.01383526,0.0001099173,0.001842209,0.04200436],"study_design_scores_gemma":[0.3359741,0.5923938,0.05685364,0.00007984386,0.002896767,0.0005223607,0.00007063716,0.003219381,0.005371422,0.0002394182,0.00233088,0.00004773623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974534,0.0009080044,0.0002021894,0.00008074903,0.00004378545,0.0002482705,0.0004649441,0.00002135205,0.0005773273],"genre_scores_gemma":[0.9975744,0.0004480613,0.0002808094,0.0001146935,0.00004194394,0.0003220829,0.0006250264,0.000005895387,0.0005871577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206916,"threshold_uncertainty_score":0.00738287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06613375915990369,"score_gpt":0.3750803175305452,"score_spread":0.3089465583706414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}