{"id":"W3028973751","doi":"10.1200/jco.2020.38.15_suppl.10512","title":"Temsirolimus combined with etoposide and cyclophosphamide for relapsed/refractory acute lymphoblastic leukemia: Therapeutic advances in Childhood Leukemia Consortium (TACL 2014-001) trial.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; BC Children's Hospital; University of Toronto","funders":"","keywords":"Medicine; Internal medicine; Temsirolimus; Etoposide; Gastroenterology; Mucositis; Febrile neutropenia; Leukopenia; Neutropenia; Toxicity; Chemotherapy; PI3K/AKT/mTOR pathway; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100802,0.0007086678,0.001153135,0.0003182003,0.000243113,0.0006843539,0.0005306003,0.000709686,0.003421588],"category_scores_gemma":[0.0003811763,0.0002666804,0.0006187523,0.0003867556,0.0004188939,0.0004254615,0.0003648394,0.001966791,0.0005852445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077666,"about_ca_system_score_gemma":0.001025513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000957678,"about_ca_topic_score_gemma":0.003157796,"domain_scores_codex":[0.99967,0.0001859629,0.00001310406,0.00003681278,0.00003624855,0.00005791452],"domain_scores_gemma":[0.9998123,0.00002216257,0.00005238778,0.00001071198,0.000008652962,0.00009375603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6262987,0.01941393,0.02118946,0.002665617,0.003375541,0.0007347029,0.0002974033,0.006305759,0.02092489,0.002415101,0.03212851,0.2642504],"study_design_scores_gemma":[0.7597033,0.1650372,0.04570782,0.0003251858,0.001466784,0.001027278,0.0001007442,0.003446971,0.003227471,0.0007415698,0.01917571,0.00003988857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830869,0.007269606,0.0004004586,0.001331513,0.0001977318,0.001168178,0.001631728,0.0001263275,0.004787556],"genre_scores_gemma":[0.9817939,0.003562627,0.001476522,0.001735892,0.0002718967,0.001695816,0.004585992,0.00002471959,0.004852625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003421588,"threshold_uncertainty_score":0.0114463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04068638683796925,"score_gpt":0.3813894030200393,"score_spread":0.3407030161820701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}