{"id":"W3029073942","doi":"10.1101/764944","title":"GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Public Health Ontario; Occupational Cancer Research Centre; Cancer Care Ontario; McGill University Health Centre; Structural Genomics Consortium; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Government of Ontario; Ontario Institute for Cancer Research; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; McGill University Health Centre; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Terry Fox Research Institute; Cancer Research Society; Princess Margaret Cancer Foundation; Pfizer","keywords":"Triple-negative breast cancer; GLUT1; Cancer research; Breast cancer; Cancer; Glucose transporter; Retinoblastoma; Medicine; Biology; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002939977,0.0005750344,0.0006995767,0.0001833425,0.00009005457,0.00007097589,0.0003677228,0.0007801907,0.00005850067],"category_scores_gemma":[0.0001051979,0.0006231201,0.0002709701,0.0003051255,0.000210115,0.00001540344,0.0005148134,0.0004925339,0.00001229488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001324041,"about_ca_system_score_gemma":0.001111776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006692415,"about_ca_topic_score_gemma":0.00002460172,"domain_scores_codex":[0.997399,0.0001406612,0.0005350218,0.001086339,0.0003397861,0.0004992096],"domain_scores_gemma":[0.997051,0.00001978959,0.000643614,0.0009416425,0.001137136,0.0002068045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002436675,0.0001421759,0.001905126,0.000267884,0.0003516753,0.000002871605,0.00001588195,0.00006522571,0.9944205,0.0001323314,0.002445724,0.000006888311],"study_design_scores_gemma":[0.001307692,0.00009839958,0.05340912,0.0003943059,0.0002309383,8.071779e-8,0.000005088966,0.00004421226,0.9407855,0.000003868057,0.003012199,0.0007086138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846465,0.005004481,0.0008722817,0.0001850254,0.003812563,0.001064367,0.004311187,0.00005954788,0.00004405766],"genre_scores_gemma":[0.9929276,0.003090602,0.000562512,0.0002577612,0.002756397,0.0002343589,0.000006545522,0.0001205626,0.00004371737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05363507,"threshold_uncertainty_score":0.999622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006829498967282805,"score_gpt":0.2149932058528779,"score_spread":0.2081637068855951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}