{"id":"W3029182802","doi":"10.1016/j.ejca.2020.04.015","title":"Adjuvant therapy with pegylated interferon-alfa2b vs observation in stage II B/C patients with ulcerated primary: Results of the European Organisation for Research and Treatment of Cancer 18081 randomised trial","year":2020,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Immunocore; Merck Sharp and Dohme; Sandoz; Bristol-Myers Squibb Canada; Genentech; SkylineDx; EORTC Charitable Trust; Sun Pharma; Sysmex Corporation; Pfizer; InflaRx; European Organisation for Research and Treatment of Cancer; Les Laboratories Pierre Fabre; Swedish Orphan Biovitrum; Array BioPharma; Roche; Regeneron Pharmaceuticals; Novartis; Sanofi; GlaxoSmithKline; Merck; Bayer; AstraZeneca; Amgen","keywords":"Medicine; Adjuvant; Pegylated interferon; Internal medicine; Stage (stratigraphy); Oncology; Adjuvant therapy; Cancer; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001586814,0.001660594,0.003748415,0.000294821,0.0003686211,0.001249579,0.0008136487,0.001612627,0.0054773],"category_scores_gemma":[0.001867187,0.0006184298,0.002972495,0.0004120664,0.0008863651,0.0009147679,0.0005381785,0.003232615,0.0007990139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001018923,"about_ca_system_score_gemma":0.0008768916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002594511,"about_ca_topic_score_gemma":0.003643781,"domain_scores_codex":[0.9992582,0.000425097,0.00004514187,0.0001230635,0.0000355206,0.0001129104],"domain_scores_gemma":[0.9991484,0.0003071512,0.0002103,0.00008579624,0.00003904974,0.0002093083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9920951,0.0005808143,0.0004858744,0.0004634637,0.001079557,0.00002053091,0.00002292289,0.0002164524,0.000568094,0.00005317046,0.000353038,0.004061133],"study_design_scores_gemma":[0.9742278,0.01988924,0.002907992,0.00009393219,0.001680935,0.00003216895,0.00002748748,0.000331539,0.0001295715,0.0002025112,0.0004641893,0.00001254325],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819103,0.01125627,0.0006051063,0.0008682272,0.0009604297,0.001036216,0.001167215,0.00007524546,0.002121004],"genre_scores_gemma":[0.9881799,0.003789881,0.0007469576,0.0009437531,0.0005262728,0.001107321,0.001227841,0.0000223131,0.003455617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0054773,"threshold_uncertainty_score":0.01832342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07156594054221829,"score_gpt":0.3098397527023926,"score_spread":0.2382738121601743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}