{"id":"W3029230186","doi":"10.1200/jco.2020.38.15_suppl.8501","title":"Weekly selinexor, bortezomib, and dexamethasone (SVd) versus twice weekly bortezomib and dexamethasone (Vd) in patients with multiple myeloma (MM) after one to three prior therapies: Initial results of the phase III BOSTON study.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Karyopharm Therapeutics","keywords":"Medicine; Bortezomib; Dexamethasone; Multiple myeloma; Internal medicine; Clinical endpoint; Surrogate endpoint; Randomization; Oncology; Phases of clinical research; Gastroenterology; Surgery; Randomized controlled trial; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003305244,0.00141535,0.001879287,0.0005421568,0.0003292224,0.0007889674,0.0008927062,0.001130954,0.00307333],"category_scores_gemma":[0.001360837,0.000568655,0.001794345,0.0004994551,0.0009340842,0.001000158,0.0004998842,0.002624987,0.0006376167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001203007,"about_ca_system_score_gemma":0.0008568012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001782627,"about_ca_topic_score_gemma":0.004078318,"domain_scores_codex":[0.9991924,0.0004793164,0.00004700086,0.0001114769,0.00007296233,0.00009674838],"domain_scores_gemma":[0.9986517,0.0003441256,0.0003449235,0.00007398805,0.00005229713,0.0005330745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9298237,0.01839691,0.007434347,0.0002607978,0.001533637,0.00004460155,0.0001209422,0.0006510468,0.004899314,0.00005936213,0.0009406661,0.03583474],"study_design_scores_gemma":[0.5063744,0.4618008,0.02743925,0.00004039259,0.0012865,0.00007816854,0.00006363579,0.0007022133,0.0008438798,0.00009990647,0.001245731,0.00002517957],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933541,0.004419287,0.0001847537,0.0004300105,0.0001070624,0.0004586061,0.0003920698,0.00003256229,0.0006215883],"genre_scores_gemma":[0.9933999,0.002117179,0.0005349239,0.0006903443,0.0002443414,0.000573677,0.0009633498,0.00001604606,0.001460285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003305244,"threshold_uncertainty_score":0.01748002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1266587915961721,"score_gpt":0.4381648612830087,"score_spread":0.3115060696868366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}