{"id":"W3029321131","doi":"10.1200/jco.2020.38.15_suppl.6070","title":"Patterns of progression and subsequent management of patients with <i>BRCA1/2</i> mutated platinum-sensitive recurrent epithelial ovarian cancer (EOC) progressing on olaparib versus placebo: the SOLO2/ENGOT Ov-21 trial (NCT01874353).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Olaparib; Internal medicine; Placebo; Clinical endpoint; Ovarian cancer; Progression-free survival; Oncology; Progressive disease; Gastroenterology; Surgery; Cancer; Urology; Chemotherapy; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009455997,0.0002413899,0.0004623365,0.0003082555,0.00012364,0.0004293249,0.0002045276,0.0004160564,0.001281373],"category_scores_gemma":[0.001156422,0.0001247751,0.0004678823,0.0002423107,0.0002048986,0.0004160304,0.0002364487,0.0005344452,0.0001131059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003336148,"about_ca_system_score_gemma":0.0002681278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002835769,"about_ca_topic_score_gemma":0.0006949903,"domain_scores_codex":[0.9996693,0.0001600107,0.00003227268,0.00005964699,0.00003910238,0.00003960317],"domain_scores_gemma":[0.9994767,0.0001514794,0.0002093921,0.00002900963,0.00001843966,0.0001150064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5894914,0.00592787,0.1431749,0.0009537609,0.001423821,0.0002940133,0.0003433637,0.00149296,0.0151358,0.0002080919,0.002290177,0.239264],"study_design_scores_gemma":[0.1227609,0.3298617,0.5272149,0.0002612299,0.002085481,0.001382277,0.0002947531,0.003500876,0.005322344,0.0007371622,0.006499453,0.00007883524],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99704,0.001727267,0.00006979749,0.00007587379,0.00001479307,0.0001059353,0.0002317294,0.000007261914,0.0007274394],"genre_scores_gemma":[0.9984637,0.0004947938,0.0001491516,0.00007862303,0.0000278158,0.00009166158,0.0004200547,0.000002253179,0.0002718141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281373,"threshold_uncertainty_score":0.00500083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1283043749164475,"score_gpt":0.4527451347805888,"score_spread":0.3244407598641413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}