{"id":"W3029437323","doi":"10.1128/mbio.00280-20","title":"The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; University of Iowa; Canada Research Chairs; Deutsche Forschungsgemeinschaft","keywords":"Human immunodeficiency virus (HIV); Virology; Binding site; Domain (mathematical analysis); Biology; Chemistry; Computational biology; Biophysics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007812765,0.0002138333,0.000173428,0.000098375,0.0002980124,0.0002985345,0.0001794992,0.000327579,0.001194066],"category_scores_gemma":[0.0001586858,0.0001350942,0.0001462948,0.00006449311,0.0003619356,0.0003746899,0.0003377379,0.0003821394,0.000417316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058401,"about_ca_system_score_gemma":0.0002170956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004572159,"about_ca_topic_score_gemma":0.0004467244,"domain_scores_codex":[0.9999404,0.000009962655,0.000001830496,0.00001184397,0.00001765487,0.00001831164],"domain_scores_gemma":[0.999956,0.000008871591,0.0000127437,0.000003440692,0.000004219018,0.00001475143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001820302,0.00003281466,0.0008847459,0.00002985337,0.000005846513,0.0002657934,0.00004807797,0.0009006885,0.9906782,0.0008287148,0.0001053122,0.006038016],"study_design_scores_gemma":[0.00008944648,0.0006500953,0.01619797,0.00002026309,0.00002316836,0.002237792,0.0001922089,0.01261483,0.9582435,0.001098557,0.008602874,0.00002922104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941348,0.0005278015,0.00330779,0.00009718188,0.000008614581,0.00001805137,0.00004239732,0.00005083648,0.001812454],"genre_scores_gemma":[0.9952963,0.000313221,0.003297906,0.00004787411,0.000004953748,0.000007823124,0.00005266525,0.000007889642,0.0009713596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194066,"threshold_uncertainty_score":0.003994524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283374980263739,"score_gpt":0.2306569352679783,"score_spread":0.2178231854653409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}