{"id":"W3029441570","doi":"10.1200/jco.2020.38.15_suppl.1005","title":"Tucatinib versus placebo added to trastuzumab and capecitabine for patients with previously treated HER2+ metastatic breast cancer with brain metastases (HER2CLIMB).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Seattle Genetics","keywords":"Medicine; Capecitabine; Internal medicine; Metastatic breast cancer; Oncology; Trastuzumab; Progression-free survival; Placebo; Breast cancer; Brain metastasis; Cancer; Surgery; Gastroenterology; Chemotherapy; Metastasis; Pathology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001067305,0.0007822232,0.00162697,0.0004161657,0.0002037578,0.0007858116,0.0005256923,0.0009664987,0.005072323],"category_scores_gemma":[0.001337016,0.0003458775,0.001249333,0.0002966068,0.0004252627,0.0007283058,0.0003336727,0.001681743,0.0005893826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007734538,"about_ca_system_score_gemma":0.0006686976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005765,"about_ca_topic_score_gemma":0.003242348,"domain_scores_codex":[0.9996309,0.0001794227,0.00003512151,0.00005157695,0.00003124233,0.00007162641],"domain_scores_gemma":[0.9995709,0.0001268163,0.000100172,0.00001767874,0.00001822869,0.0001661305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9539813,0.004046854,0.001267735,0.000544042,0.0007944311,0.00009549533,0.00005848055,0.0004502432,0.003110443,0.00009891608,0.0008105987,0.03474125],"study_design_scores_gemma":[0.5471684,0.4284338,0.01576226,0.0001421495,0.001747297,0.0002602154,0.00007332108,0.001890875,0.001650684,0.0002765091,0.002567889,0.00002647983],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885197,0.006412556,0.0001881207,0.0004306515,0.0005316893,0.0009333859,0.0004077929,0.00006135669,0.002514758],"genre_scores_gemma":[0.9955359,0.001616639,0.0002159933,0.0002938649,0.0002166282,0.0004517153,0.0003388868,0.00000462015,0.001325733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005072323,"threshold_uncertainty_score":0.01696861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09446764775303201,"score_gpt":0.4272581679754395,"score_spread":0.3327905202224075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}