{"id":"W3029441570","doi":"10.1200/jco.2020.38.15_suppl.1005","title":"Tucatinib versus placebo added to trastuzumab and capecitabine for patients with previously treated HER2+ metastatic breast cancer with brain metastases (HER2CLIMB).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Seattle Genetics","keywords":"Medicine; Capecitabine; Internal medicine; Metastatic breast cancer; Oncology; Trastuzumab; Progression-free survival; Placebo; Breast cancer; Brain metastasis; Cancer; Surgery; Gastroenterology; Chemotherapy; Metastasis; Pathology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118813,0.0003199696,0.002094888,0.00009605597,0.00006482527,0.0000206765,0.0001226994,0.0001112965,0.0002579379],"category_scores_gemma":[0.001878151,0.000177746,0.0002828107,0.0002739871,0.000173394,0.0001224544,0.00003295726,0.000429409,0.000004934342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733063,"about_ca_system_score_gemma":0.001290836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006362983,"about_ca_topic_score_gemma":0.0003002429,"domain_scores_codex":[0.9968054,0.0004667061,0.001505619,0.0004009982,0.0004371984,0.0003840436],"domain_scores_gemma":[0.9929233,0.003886452,0.001160709,0.0001786012,0.0006962013,0.001154697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4827773,0.01091142,0.1103855,0.0003587348,0.01152059,0.0009985979,0.0009676834,0.0001606717,0.00002710955,0.00006587564,0.02493792,0.3568887],"study_design_scores_gemma":[0.2561361,0.3504666,0.3066921,0.0005069045,0.012585,0.0005512616,0.001063699,0.0001522103,0.00006239222,0.00001959971,0.07124132,0.0005228422],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9538192,0.0003836951,0.0005051288,0.04272139,0.0002136791,0.001876222,0.0003649186,0.00001747395,0.00009831494],"genre_scores_gemma":[0.9560144,0.0001441308,0.03621511,0.006783402,0.0005111928,0.0001235804,0.00005916075,0.00006204702,0.00008699914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3563658,"threshold_uncertainty_score":0.7248271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09446764775303201,"score_gpt":0.4272581679754395,"score_spread":0.3327905202224075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}