{"id":"W3029511382","doi":"10.1200/jco.2020.38.15_suppl.3581","title":"A phase Ib study of oral Chk1 inhibitor LY2880070 in combination with gemcitabine in patients with advanced or metastatic cancer.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; McGill University Health Centre; Jewish General Hospital; McGill University; Princess Margaret Cancer Centre; Ottawa Hospital; Ozmosis Research (Canada); Université de Montréal; University of Alberta","funders":"","keywords":"Medicine; Gemcitabine; Nausea; Adverse effect; Vomiting; Pharmacokinetics; Dosing; Cancer; Pharmacology; Internal medicine; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001078768,0.001455258,0.002458299,0.0006263496,0.0004654646,0.001198296,0.0009591965,0.001306879,0.003834894],"category_scores_gemma":[0.0007118434,0.0006706013,0.001127827,0.0005752112,0.000958722,0.0008878147,0.0004780247,0.002731047,0.001019334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009932867,"about_ca_system_score_gemma":0.001809469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237685,"about_ca_topic_score_gemma":0.003225486,"domain_scores_codex":[0.9996485,0.0001569064,0.00002033692,0.00006686647,0.00003358239,0.0000737332],"domain_scores_gemma":[0.9995597,0.00006815383,0.00006736752,0.00003581416,0.00002552897,0.0002434747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6493552,0.1195795,0.005370534,0.002038733,0.001636217,0.0005822001,0.0005644286,0.005903614,0.08427649,0.0005437362,0.00564134,0.1245081],"study_design_scores_gemma":[0.4247749,0.5559675,0.008183714,0.00005418467,0.0005117849,0.000354179,0.00009410305,0.001722619,0.004496641,0.0002030202,0.003597102,0.00004033419],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876636,0.00283802,0.0007678382,0.0004841086,0.0001621254,0.004180278,0.001141621,0.0001597859,0.002602585],"genre_scores_gemma":[0.9855378,0.003081468,0.001714599,0.0008040437,0.0001484091,0.003157819,0.002579464,0.00004182982,0.002934533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003834894,"threshold_uncertainty_score":0.01282901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396747945565349,"score_gpt":0.5086751694984455,"score_spread":0.3690003749419106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}