{"id":"W3029538724","doi":"10.1101/2020.05.26.115006","title":"HIV Diversity Considerations in the Application of the Intact Proviral DNA Assay (IPDA)","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; AIDS Vancouver; Maple Leaf Medical Clinic; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Digital polymerase chain reaction; Human immunodeficiency virus (HIV); Computational biology; Biology; DNA; Virology; Genetics; Gene; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03643259,0.001116732,0.00129149,0.00162426,0.0007520079,0.004822927,0.002186134,0.003039732,0.005170229],"category_scores_gemma":[0.05510124,0.0007749282,0.0008932529,0.001149843,0.00217034,0.002071547,0.001988025,0.003246297,0.004490234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001028928,"about_ca_system_score_gemma":0.001427962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006240511,"about_ca_topic_score_gemma":0.000964299,"domain_scores_codex":[0.9718185,0.01517394,0.001956859,0.003019084,0.007500308,0.0005313199],"domain_scores_gemma":[0.9612049,0.02912374,0.001484297,0.002542243,0.005253708,0.0003911505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001806061,0.0002721741,0.02268046,0.005501321,0.0002834397,0.001731901,0.001256513,0.003531412,0.2035101,0.04187897,0.06341802,0.6541297],"study_design_scores_gemma":[0.0001964725,0.002868114,0.02465167,0.002331806,0.0003256465,0.005956657,0.0009335473,0.01539964,0.4071722,0.03822493,0.5015506,0.0003886229],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.08041546,0.1225674,0.6543289,0.04900031,0.03192532,0.002987112,0.005632491,0.003113449,0.05002955],"genre_scores_gemma":[0.3814033,0.02942089,0.530405,0.01946524,0.008093249,0.004064933,0.002517047,0.001385902,0.0232445],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.03643259,"threshold_uncertainty_score":0.1926763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089003923332418,"score_gpt":0.2326459722915063,"score_spread":0.2117559330581822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}