{"id":"W3029596757","doi":"10.15698/mic2020.06.719","title":"Broad-spectrum antifungal activities and mechanism of drimane sesquiterpenoids","year":2020,"lang":"en","type":"article","venue":"Microbial Cell","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; University of Missouri-Kansas City; University of Missouri","keywords":"Candida albicans; Antifungal; Broad spectrum; Fungicide; Chemistry; Cryptococcus neoformans; Fungal pathogen; Aspergillus; Stereochemistry; Microbiology; Biology; Botany; Pathogen; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566594,0.0004592512,0.000273843,0.0004649502,0.0001213527,0.0002058254,0.0002020501,0.000225235,0.001501066],"category_scores_gemma":[0.00007856066,0.0001183822,0.0002698319,0.0001715539,0.0002144745,0.0002788725,0.0001955339,0.0002935639,0.0003601652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001274585,"about_ca_system_score_gemma":0.0001293982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003849258,"about_ca_topic_score_gemma":0.0006578324,"domain_scores_codex":[0.9999431,0.00001235447,0.000006352918,0.000008839335,0.00001491784,0.00001447708],"domain_scores_gemma":[0.9999354,0.000007639163,0.00001662156,0.000005666353,0.00001442488,0.00002033312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636242,0.00003280536,0.0002717299,0.0001013579,0.000009346424,0.0001399086,0.00001707613,0.0001941363,0.9949432,0.0001369367,0.00002472731,0.00396506],"study_design_scores_gemma":[0.00005121308,0.001084417,0.004647283,0.00001642922,0.00003323716,0.000358291,0.00004262822,0.0003234445,0.9904557,0.0001138772,0.002860744,0.00001261051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854923,0.008366256,0.00175678,0.0001288016,0.00001741851,0.00009251822,0.0005385438,0.0000488251,0.003558573],"genre_scores_gemma":[0.9917891,0.003774511,0.001486657,0.00008780471,0.00001100534,0.00003720414,0.0004087216,0.000004866616,0.002400104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501066,"threshold_uncertainty_score":0.005021513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00547998497809004,"score_gpt":0.1924461913065515,"score_spread":0.1869662063284614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}