{"id":"W3029613337","doi":"10.1101/605303","title":"Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Genome Canada; Ontario Genomics; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Chromatin; Histone; Small molecule; Histone methyltransferase; Acetylation; Biology; Histone H3; Chemistry; Biochemistry; Computational biology; Cell biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187249,0.0003246614,0.0004120578,0.0002563694,0.0001919841,0.000242576,0.0004917603,0.000317952,0.003065226],"category_scores_gemma":[0.0003246218,0.0001221394,0.0003398698,0.0003299476,0.000160291,0.000141214,0.0002503817,0.0005619188,0.0007303496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004193955,"about_ca_system_score_gemma":0.0002510968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024127,"about_ca_topic_score_gemma":0.001140722,"domain_scores_codex":[0.9998713,0.00001965572,0.000008846138,0.00001969858,0.00005223133,0.00002840326],"domain_scores_gemma":[0.9998786,0.0000273764,0.00001871152,0.00001110738,0.00002649823,0.00003770119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001455435,0.00004391253,0.0003196952,0.00004532794,0.000014334,0.00008031049,0.00001627773,0.0003012823,0.9967961,0.0001003833,0.0001321326,0.002004773],"study_design_scores_gemma":[0.00005122035,0.0005695358,0.002383417,0.000005534937,0.00003293152,0.0003340553,0.00002728599,0.001183357,0.9921091,0.00003671045,0.003258517,0.000008342194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983451,0.002303504,0.009546843,0.0001609258,0.0000344557,0.0002354557,0.002155153,0.0000949506,0.002017741],"genre_scores_gemma":[0.9793589,0.0008861722,0.009625353,0.0001127654,0.00001188435,0.0001268788,0.005765399,0.00002833256,0.00408436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003065226,"threshold_uncertainty_score":0.0102542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005824835075241091,"score_gpt":0.2013784880477416,"score_spread":0.1955536529725005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}