{"id":"W3029613337","doi":"10.1101/605303","title":"Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Genome Canada; Ontario Genomics; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Chromatin; Histone; Small molecule; Histone methyltransferase; Acetylation; Biology; Histone H3; Chemistry; Biochemistry; Computational biology; Cell biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851882,0.0002349621,0.0002186258,0.00006292862,0.00009719964,0.00005316478,0.0002490345,0.0004379475,0.000003347187],"category_scores_gemma":[0.00005054341,0.0002249957,0.0001081779,0.0001224101,0.00006859544,0.000007311652,0.0002796723,0.0001236909,0.000002328386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007993857,"about_ca_system_score_gemma":0.000210023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005219141,"about_ca_topic_score_gemma":0.000003716469,"domain_scores_codex":[0.9986577,0.00004700417,0.0003775468,0.000571423,0.0001683251,0.0001780256],"domain_scores_gemma":[0.9982087,0.000009502008,0.0005572555,0.0008676225,0.0003111311,0.00004576953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004054681,0.00003208011,0.002575095,0.000345317,0.00008809734,6.629814e-8,0.000007378043,0.0001914074,0.9965024,0.00006397352,0.0001488691,0.000004741803],"study_design_scores_gemma":[0.0003592872,0.00003412819,0.2043734,0.0001430526,0.00006522155,8.243075e-9,8.346453e-7,0.0004099801,0.7850805,0.000001885089,0.009317334,0.0002143473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877965,0.0004386101,0.008438577,0.000411812,0.001042749,0.001423139,0.0004280693,0.00001962882,9.327115e-7],"genre_scores_gemma":[0.9987461,0.0002210364,0.000333148,0.00006274677,0.0003240609,0.0002243757,0.000009579547,0.000057642,0.0000213068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2114219,"threshold_uncertainty_score":0.9175057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005824835075241091,"score_gpt":0.2013784880477416,"score_spread":0.1955536529725005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}