{"id":"W3029637120","doi":"10.1200/jco.19.03355","title":"ASCEND: Phase III, Randomized Trial of Acalabrutinib Versus Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":362,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; University of New Brunswick","funders":"","keywords":"Bendamustine; Idelalisib; Medicine; Rituximab; Chronic lymphocytic leukemia; Refractory (planetary science); Internal medicine; Oncology; Leukemia; Lymphoma; Ibrutinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002147524,0.002210519,0.002138454,0.0006047693,0.0004488692,0.001151824,0.001058885,0.001186161,0.005757434],"category_scores_gemma":[0.001536413,0.0005313787,0.001471911,0.0004181207,0.00120945,0.001068056,0.000621294,0.002957048,0.0009711274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008588441,"about_ca_system_score_gemma":0.001301153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007616371,"about_ca_topic_score_gemma":0.002397696,"domain_scores_codex":[0.9993087,0.0004254128,0.00003088712,0.0001000441,0.00004962004,0.00008529762],"domain_scores_gemma":[0.9990968,0.0001892411,0.0002233554,0.00005380446,0.00005023011,0.0003866543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9786471,0.004329437,0.0006562803,0.0003368892,0.0005247095,0.00003115743,0.00002917725,0.0004361286,0.001335801,0.0001865375,0.001770716,0.01171608],"study_design_scores_gemma":[0.9589285,0.03733464,0.001135966,0.000022862,0.0002851037,0.00002815775,0.00001711301,0.0005323527,0.0002889922,0.0002335107,0.001183963,0.00000889562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970742,0.005977568,0.001171637,0.001499301,0.001133166,0.009811549,0.003299345,0.0003496839,0.006015638],"genre_scores_gemma":[0.9715133,0.003191135,0.002561045,0.002037353,0.0009846411,0.01136594,0.002990548,0.00004103008,0.005315019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005757434,"threshold_uncertainty_score":0.01926047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2071622178590186,"score_gpt":0.5057558719860992,"score_spread":0.2985936541270806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}