{"id":"W3029693493","doi":"10.1002/jgm.3234","title":"Evaluation of DNA methylation status of toll‐like receptors 2 and 4 promoters in Behcet's disease","year":2020,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Ocular Diseases and Behçet’s Syndrome","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"TLR2; Methylation; Promoter; TLR4; DNA methylation; CpG site; Peripheral blood mononuclear cell; Innate immune system; Bisulfite sequencing; Receptor; Immunology; Biology; Molecular biology; Pathogenesis; Immune system; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656236,0.0001871412,0.0002385597,0.0007920786,0.0001677004,0.0002060606,0.0001421776,0.0002265642,0.001467705],"category_scores_gemma":[0.0005061752,0.0001262075,0.000196417,0.0004306422,0.0001302977,0.0001083002,0.0001313804,0.0002260954,0.0001915995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001216444,"about_ca_system_score_gemma":0.00009699527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005527299,"about_ca_topic_score_gemma":0.0007218132,"domain_scores_codex":[0.9998199,0.00004355859,0.00001693428,0.00004445745,0.00004497653,0.00003016004],"domain_scores_gemma":[0.9997544,0.00006533703,0.0001012286,0.00001322941,0.00003958758,0.00002627718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005323727,0.0001737425,0.6336172,0.0004776181,0.0003997505,0.0005361316,0.0006854311,0.0005188346,0.3196525,0.0001596132,0.0004478022,0.03800757],"study_design_scores_gemma":[0.00008479571,0.001023637,0.9229171,0.00005655732,0.0003617337,0.002461942,0.0004205514,0.001773417,0.06806882,0.0003307624,0.002480187,0.00002049391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957067,0.002348303,0.0008133721,0.0000321359,0.00001185271,0.00001787943,0.000555334,0.00001521507,0.0004992025],"genre_scores_gemma":[0.9974406,0.0005177177,0.001022599,0.00002925868,0.00001314683,0.00003502033,0.0005102089,0.000004393185,0.000426963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467705,"threshold_uncertainty_score":0.004909933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04968700712188146,"score_gpt":0.3214019070107706,"score_spread":0.2717148998888892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}