{"id":"W3029786930","doi":"10.1200/jco.2020.38.15_suppl.tps8551","title":"GO39775: A multicenter phase I trial evaluating the safety, pharmacokinetics, and activity of BFCR4350A, a FcRH5/CD3 T-cell dependent bispecific antibody, in patients with relapsed or refractory multiple myeloma.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Genentech","keywords":"Multiple myeloma; Medicine; Antibody; Bone marrow; Plasma cell; CD3; Cancer research; CD8; Immunology; Internal medicine; Immune system; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007580576,0.001512543,0.001622476,0.0005659026,0.0003427876,0.001030129,0.0009082179,0.001298191,0.007044507],"category_scores_gemma":[0.0005149834,0.0004487214,0.00133871,0.0006319179,0.0007472272,0.0008197742,0.0004717764,0.003459351,0.001544148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001193373,"about_ca_system_score_gemma":0.001313449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277605,"about_ca_topic_score_gemma":0.003542288,"domain_scores_codex":[0.9997762,0.0000642473,0.00000786261,0.00005308211,0.0000313558,0.00006733169],"domain_scores_gemma":[0.9997364,0.00002378407,0.00005056979,0.00001750543,0.00001641056,0.0001553163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5628358,0.0499142,0.006857344,0.002581844,0.003749305,0.0008595657,0.0004515907,0.005583327,0.09577942,0.001719384,0.02341985,0.2462484],"study_design_scores_gemma":[0.5773169,0.3839518,0.01256667,0.0001873481,0.001148718,0.001169226,0.0001527292,0.002764478,0.005509074,0.001118742,0.01403333,0.00008104768],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809659,0.006990504,0.0006773021,0.001434466,0.0002752827,0.00176074,0.002781051,0.0003553322,0.004759457],"genre_scores_gemma":[0.9768942,0.004229272,0.001392567,0.002665982,0.0001497373,0.002133052,0.006718543,0.00008120948,0.00573536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007044507,"threshold_uncertainty_score":0.02356619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2028929584710856,"score_gpt":0.5178645756702588,"score_spread":0.3149716171991732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}