{"id":"W3029873699","doi":"10.1021/acschemneuro.0c00176","title":"Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases","year":2020,"lang":"en","type":"review","venue":"ACS Chemical Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Pharmaceuticals Bayer; Merck Sharp and Dohme; Genentech; National Institutes of Health; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; ALS Association; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; AbbVie; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Merck KGaA; Innovative Medicines Initiative; Wellcome; National Institute of Diabetes and Digestive and Kidney Diseases; Boehringer Ingelheim; Pfizer","keywords":"Kinome; Drug discovery; Kinase; Amyotrophic lateral sclerosis; Neuroscience; Disease; Drug development; Small molecule; Drug; Computational biology; Neurodegeneration; Medicine; Biology; Bioinformatics; Pharmacology; Cell biology; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004165938,0.0008081987,0.0009815828,0.002162684,0.0003201957,0.001232612,0.0006925199,0.001038584,0.003873823],"category_scores_gemma":[0.0004134974,0.0002734436,0.0004248931,0.001702458,0.0006250571,0.002021833,0.0008447611,0.002100372,0.002500599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008857606,"about_ca_system_score_gemma":0.0009608279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008731763,"about_ca_topic_score_gemma":0.001938337,"domain_scores_codex":[0.9998823,0.00001938904,0.00001237665,0.00002256821,0.00004593327,0.00001738178],"domain_scores_gemma":[0.9998369,0.00007665166,0.0000198095,0.000006290463,0.00004199011,0.0000183804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00006432946,0.00008372591,0.0001171885,0.01784403,0.00006503012,0.0002597878,0.00009593659,0.0006572675,0.005599802,0.02011473,0.0268064,0.9282919],"study_design_scores_gemma":[0.00001046281,0.0000799526,0.0003095523,0.001980216,0.00003903426,0.0006099453,0.00006519812,0.0001452862,0.000907862,0.004779896,0.9910555,0.00001710581],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001580601,0.996905,0.0003949074,0.0003502704,0.0002160761,0.000006884155,0.00002071973,0.0000122514,0.001935828],"genre_scores_gemma":[0.0009224562,0.9973304,0.0003291863,0.0002285824,0.0001099942,0.000009293262,0.000030244,0.000001956277,0.001037917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003873823,"threshold_uncertainty_score":0.01295924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09374240231430611,"score_gpt":0.3378624169568213,"score_spread":0.2441200146425152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}