{"id":"W3029875695","doi":"10.1083/jcb.201908132","title":"LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation","year":2020,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Fundação para a Ciência e a Tecnologia; Canadian Institutes of Health Research; Fondo Nacional de Ciencia y Tecnología; Krembil Foundation","keywords":"Ciliogenesis; Centrosome; Cilium; Cell biology; Basal body; Biology; Ciliopathies; Microtubule; Flagellum; Motile cilium; Motility; Actin; Cell; Phenotype; Genetics; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007615083,0.0002225235,0.0002080086,0.0002531935,0.0001567034,0.0003787804,0.0002253957,0.0002730896,0.001175745],"category_scores_gemma":[0.0001447777,0.0001562421,0.0001401232,0.0001261926,0.0002052841,0.0002131774,0.000345572,0.000479138,0.0003333121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003640357,"about_ca_system_score_gemma":0.0001530239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003135082,"about_ca_topic_score_gemma":0.0006751607,"domain_scores_codex":[0.9999173,0.00001168441,0.000006314567,0.00001738391,0.00002228114,0.00002509127],"domain_scores_gemma":[0.9999106,0.00001218952,0.00002730864,0.000005692514,0.000008124915,0.00003616624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001476951,0.00001995419,0.0004515721,0.0000341378,0.000006239455,0.00008471616,0.00001024768,0.0001198434,0.996806,0.0002039117,0.0001304333,0.001985227],"study_design_scores_gemma":[0.00006387208,0.0002636479,0.02239215,0.00001055637,0.00004018653,0.000536619,0.0000808297,0.003854673,0.9669015,0.0002442944,0.005601832,0.000009898698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994629,0.001947808,0.001652455,0.0001718276,0.00002744817,0.0000104258,0.000208157,0.00007392285,0.001279112],"genre_scores_gemma":[0.9969463,0.0006919418,0.0005349743,0.00006519664,0.000006130423,0.00001690149,0.0001831319,0.00001844311,0.001536997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175745,"threshold_uncertainty_score":0.003933191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194459327433559,"score_gpt":0.2210083574390061,"score_spread":0.2090637641646705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}