{"id":"W3029895260","doi":"10.1016/j.celrep.2020.107693","title":"MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; National Health Research Institutes","keywords":"Zebrafish; RNA Helicase A; Cell biology; Gene knockdown; Nuclear pore; Biology; RNA-binding protein; SUMO protein; Nuclear transport; Ribonucleoprotein; Nuclear export signal; Ubiquitin; Ubiquitin ligase; DEAD box; Messenger RNA; Nucleoporin; Nucleolin; RNA; Helicase; Genetics; Cell nucleus; Cytoplasm; Gene; Nucleolus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154559,0.0001234016,0.000127451,0.00001732233,0.00005928241,0.00004045039,0.00007152221,0.00004450735,0.00001215886],"category_scores_gemma":[0.00006924496,0.0001014242,0.00002539683,0.00006777838,0.00003090952,0.000004368816,0.0001573297,0.00008383291,0.000006869199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009732617,"about_ca_system_score_gemma":0.0001357949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005853124,"about_ca_topic_score_gemma":0.000006592225,"domain_scores_codex":[0.9989246,0.00001479134,0.0002063158,0.0004250991,0.0001873878,0.0002418118],"domain_scores_gemma":[0.9992769,0.000004057789,0.00008154375,0.0002165782,0.00007741599,0.0003434492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001397654,0.00002648247,0.003618155,0.00003064026,0.00001906483,0.0005754236,0.0001577004,0.00001095569,0.9887235,0.000001154301,0.00376617,0.002931029],"study_design_scores_gemma":[0.000177561,0.0004381449,0.01401994,0.00003168551,0.000005274143,0.0001486683,0.00005174098,0.0000181757,0.9316068,0.00000407471,0.05332327,0.0001746558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953963,0.00006284913,0.000482641,0.0004543652,0.00002442686,0.0001741754,4.647151e-7,0.00001278304,0.003391988],"genre_scores_gemma":[0.9943619,0.00001025962,0.002206121,0.0007113914,0.0001185478,0.00001427555,0.00002847499,0.00001946391,0.002529551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05711664,"threshold_uncertainty_score":0.4135959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009435951302625145,"score_gpt":0.2307716895612655,"score_spread":0.2213357382586403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}