{"id":"W3029941476","doi":"10.1200/jco.2020.38.15_suppl.10506","title":"Dabrafenib + trametinib combination therapy in pediatric patients with BRAF V600-mutant low-grade glioma: Safety and efficacy results.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Novartis","keywords":"Medicine; Trametinib; Dabrafenib; Tolerability; Oncology; Adverse effect; Internal medicine; Combination therapy; Glioma; Pediatric cancer; Neurocognitive; Cohort; Discontinuation; Clinical trial; Cancer; MAPK/ERK pathway; Cancer research; Vemurafenib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005776816,0.000526452,0.0009505081,0.0002856702,0.0001981022,0.0004558688,0.0003201084,0.0003130656,0.001379558],"category_scores_gemma":[0.0004478208,0.0002252473,0.0007487322,0.000437452,0.00024682,0.0003352235,0.0001683245,0.001127846,0.0004373471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008459787,"about_ca_system_score_gemma":0.000874881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001257812,"about_ca_topic_score_gemma":0.004419555,"domain_scores_codex":[0.9997723,0.000096385,0.00002330007,0.00003144284,0.00003979573,0.00003691126],"domain_scores_gemma":[0.9997235,0.00004112893,0.00009997137,0.00001958281,0.00002551241,0.00009025315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2102887,0.02178828,0.06846254,0.002582393,0.003465781,0.001702002,0.0004861481,0.004009158,0.06129351,0.0003513002,0.01044752,0.6151226],"study_design_scores_gemma":[0.1148769,0.5624385,0.2413722,0.0003625828,0.004141543,0.00797345,0.0003495483,0.005690222,0.02218289,0.0003012381,0.04021035,0.0001004623],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832721,0.01237353,0.0004667803,0.0003060802,0.00004335472,0.0004417693,0.001150389,0.00005989895,0.001886048],"genre_scores_gemma":[0.9865753,0.008664628,0.001485082,0.0003235645,0.00005835272,0.0002516854,0.001890365,0.0000177543,0.000733237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379558,"threshold_uncertainty_score":0.006138086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06215398273533818,"score_gpt":0.3858303784684231,"score_spread":0.3236763957330849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}