{"id":"W3030023178","doi":"10.1111/hae.14023","title":"Uncertainty in an era of transformative therapy for haemophilia: Addressing the unknowns","year":2020,"lang":"en","type":"article","venue":"Haemophilia","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Haemophilia; Medicine; Clinical trial; Haemophilia A; Acknowledgement; Gene transfer; Genetic enhancement; Intensive care medicine; Transformative learning; Gene; Surgery; Computer science; Pathology; Biology; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03253428,0.0009707133,0.002124912,0.00117637,0.003561167,0.009362937,0.002212021,0.01010771,0.005802537],"category_scores_gemma":[0.02503722,0.00052521,0.001094189,0.0007785403,0.01946619,0.02151229,0.0067837,0.02425855,0.002245015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005710811,"about_ca_system_score_gemma":0.008309457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198201,"about_ca_topic_score_gemma":0.001355618,"domain_scores_codex":[0.9895745,0.00367786,0.0007119352,0.001209577,0.00399702,0.0008291018],"domain_scores_gemma":[0.9745797,0.01564189,0.001310327,0.001601693,0.004251168,0.002615097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006951303,0.0003266187,0.001073083,0.002679233,0.0001198174,0.0009537936,0.004567777,0.001562574,0.008452634,0.5971807,0.1501513,0.2322375],"study_design_scores_gemma":[0.00004050614,0.0003092873,0.0003416978,0.001139389,0.00004083992,0.0006718416,0.001859975,0.0004106317,0.001776253,0.3137985,0.6795378,0.00007324299],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.00395303,0.3282698,0.01115074,0.6303307,0.01364058,0.0000342014,0.0001383469,0.0001650022,0.01231756],"genre_scores_gemma":[0.1368167,0.4713751,0.02155178,0.3187014,0.03548708,0.0002762325,0.0003218521,0.0004211794,0.01504854],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03253428,"threshold_uncertainty_score":0.1720598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04787332188454652,"score_gpt":0.3425752217972616,"score_spread":0.2947018999127151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}