{"id":"W3030062209","doi":"10.1200/jco.2020.38.15_suppl.tps11571","title":"Safety and activity of autologous T cells with enhanced NY-ESO-1–specific T-cell receptor (GSK3377794) in HLA-a*02<sup>+</sup> previously-treated and -untreated patients with advanced metastatic/unresectable synovial sarcoma: A master protocol study design (IGNYTE-ESO).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Princess Margaret Cancer Centre; Mount Sinai Hospital","funders":"GlaxoSmithKline","keywords":"Medicine; Synovial sarcoma; Soft tissue sarcoma; Internal medicine; Oncology; Progressive disease; Chemotherapy; Sarcoma; Immunology; Cancer research; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004193756,0.001314148,0.001704104,0.0005284622,0.0003997478,0.0008848672,0.001017754,0.00158875,0.003191814],"category_scores_gemma":[0.002080363,0.0006538376,0.00126637,0.0005315145,0.001442878,0.001008134,0.0005026397,0.002619761,0.0006613286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001188307,"about_ca_system_score_gemma":0.002025214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005659868,"about_ca_topic_score_gemma":0.001099229,"domain_scores_codex":[0.9980007,0.001285881,0.0001244797,0.0001968224,0.0001424246,0.0002497831],"domain_scores_gemma":[0.9981717,0.0004362672,0.0005060057,0.0003101454,0.000124554,0.0004513582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8491426,0.06148662,0.006395373,0.0006121941,0.001029476,0.0001813765,0.0003431799,0.002678912,0.03861877,0.0004795635,0.001987713,0.03704428],"study_design_scores_gemma":[0.2184433,0.7692885,0.00520679,0.00002058701,0.0003096735,0.00008273733,0.00004765454,0.0007747217,0.004422619,0.000168906,0.001214774,0.00001964796],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9930819,0.0005931352,0.0006587633,0.0001258072,0.00007314143,0.00391617,0.000639499,0.00003432398,0.0008773732],"genre_scores_gemma":[0.986998,0.0004958747,0.001480222,0.0003520963,0.0001481482,0.008363423,0.001016823,0.00002027165,0.001125209],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.004193756,"threshold_uncertainty_score":0.02217895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08339887970369389,"score_gpt":0.392426148073323,"score_spread":0.3090272683696291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}