{"id":"W3030139823","doi":"10.3390/insects11060327","title":"RNA Interference Is Enhanced by Knockdown of Double-Stranded RNases in the Yellow Fever Mosquito Aedes aegypti","year":2020,"lang":"en","type":"article","venue":"Insects","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fisheries and Oceans Canada; University of Manitoba","funders":"Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"RNA interference; Biology; RNA silencing; Aedes aegypti; Gene knockdown; Midgut; RNA; Gene silencing; Aedes; Insect; Virology; Small interfering RNA; Mosquito control; Larva; Gene; Genetics; Botany; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008100087,0.0001589605,0.0001684301,0.00002076162,0.00003723606,0.00002395402,0.0003786623,0.0001262991,0.0000510079],"category_scores_gemma":[0.00002786162,0.0001232665,0.00008257537,0.0001547597,0.00009214015,0.00000453476,0.00006025976,0.0001174907,0.000009138551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006777667,"about_ca_system_score_gemma":0.00006278915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005931091,"about_ca_topic_score_gemma":0.0002103636,"domain_scores_codex":[0.9990419,0.00005006756,0.0002397284,0.0002923722,0.0001524578,0.0002234692],"domain_scores_gemma":[0.9995024,0.00001822133,0.0000813375,0.0002856709,0.00006088877,0.00005150434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000362087,0.00005386244,0.0003233762,0.00004906455,0.00002544435,0.000003283733,0.0012683,0.00002362392,0.9863605,0.0000115839,0.01061671,0.0009020889],"study_design_scores_gemma":[0.0009501704,0.000354719,0.0007999691,0.0000301932,0.00001154715,0.000001516655,0.0002092476,0.0000137022,0.9902859,0.00004713633,0.00714301,0.0001529282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946882,0.0008673652,0.0003481166,0.0005905842,0.00006555851,0.0001953098,0.00003279509,0.000006658107,0.003205415],"genre_scores_gemma":[0.997122,0.0003968491,0.00008199263,0.001969969,0.0001097656,0.00001927935,0.0000339652,0.00001362036,0.0002524955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003925286,"threshold_uncertainty_score":0.5026661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198839740172687,"score_gpt":0.2529568592909683,"score_spread":0.2330728852736996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}