{"id":"W3030217950","doi":"10.1016/j.oraloncology.2020.104753","title":"Phase I trial of alpelisib in combination with concurrent cisplatin-based chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck","year":2020,"lang":"en","type":"article","venue":"Oral Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Canada; Novartis Pharmaceuticals Corporation","keywords":"Medicine; Internal medicine; Mucositis; Neutropenia; Oncology; Head and neck cancer; Cisplatin; Radiation therapy; Surgery; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007313384,0.0001124524,0.0002745726,0.00002905973,0.00001101477,0.000002058978,0.0001145387,0.00009675831,0.000005092378],"category_scores_gemma":[0.00002558301,0.00008038236,0.00002730003,0.0001384277,0.0001505728,0.000003715936,0.00002100214,0.00009261278,8.292794e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004837454,"about_ca_system_score_gemma":0.0002974286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003238881,"about_ca_topic_score_gemma":0.0001549212,"domain_scores_codex":[0.9991988,0.00009189775,0.000240804,0.0002194962,0.000128249,0.0001207314],"domain_scores_gemma":[0.9994767,0.00003079899,0.0002371048,0.00012601,0.00009177566,0.00003762213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1873016,0.006151968,0.6104453,0.000175083,0.00002847096,0.00001091351,0.0004945027,0.003110381,0.1664257,0.00004653455,0.0001910678,0.02561853],"study_design_scores_gemma":[0.5669292,0.08110109,0.1108484,0.0000621926,0.00003172715,0.000001331847,0.00004318912,0.001285043,0.2376531,0.00001097054,0.001747763,0.0002858907],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986953,0.0001305024,0.0001379507,0.0002790749,0.00006348557,0.0006203791,0.00002185708,0.000001779881,0.00004974171],"genre_scores_gemma":[0.9991646,0.000003522941,0.0004016653,0.0003131443,0.00002156649,0.00002874655,0.00004971639,0.00001315622,0.000003897849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4995968,"threshold_uncertainty_score":0.3277898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378498509390629,"score_gpt":0.2812066178078284,"score_spread":0.2674216327139221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}