{"id":"W3030310275","doi":"10.1021/acssynbio.0c00148","title":"Dynamic Cell Programming with Quorum Sensing-Controlled CRISPRi Circuit","year":2020,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario Ministry of Research, Innovation and Science","keywords":"Quorum sensing; Synthetic biology; Biomanufacturing; Computer science; Computational biology; Systems biology; Population; Biology; Biochemical engineering; Biotechnology; Engineering; Bacteria; Genetics; Biofilm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001607069,0.0004747045,0.0004018662,0.0002268824,0.0002186814,0.0005257294,0.0008447917,0.0004398549,0.001443348],"category_scores_gemma":[0.0003033804,0.0002338309,0.0002673342,0.0002103184,0.0004180247,0.0004233265,0.0005049577,0.0006073817,0.0003575749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004457947,"about_ca_system_score_gemma":0.0002816753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003910631,"about_ca_topic_score_gemma":0.000503324,"domain_scores_codex":[0.9997841,0.00001634922,0.00001549724,0.00007438064,0.00006516025,0.00004457146],"domain_scores_gemma":[0.9998664,0.00003525856,0.0000361556,0.00001561784,0.0000207882,0.00002592915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004002305,0.00003933136,0.0002261428,0.0000728667,0.000005819351,0.00005804284,0.0000348543,0.002082399,0.9872226,0.001731682,0.0002535096,0.008232764],"study_design_scores_gemma":[0.00002079808,0.0001567945,0.0005181873,0.000006242966,0.00001201318,0.0001090986,0.00001715355,0.03738123,0.9547087,0.0005851479,0.006458831,0.00002576399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5962883,0.001440868,0.3831948,0.0005456608,0.0003709616,0.0004033935,0.0006195477,0.004168288,0.01296819],"genre_scores_gemma":[0.915257,0.0005167529,0.07914259,0.0002437366,0.00002043453,0.000290221,0.0002318564,0.0001453718,0.004152105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443348,"threshold_uncertainty_score":0.004828513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006910286148679296,"score_gpt":0.2636439077204276,"score_spread":0.2567336215717483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}