{"id":"W3030320535","doi":"10.1101/591164","title":"A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Western Economic Diversification Canada; Wellcome Trust; National Cancer Institute; National Research Council Canada; Beijing Municipal Administration of Hospitals; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Susan G. Komen for the Cure; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Memorial Sloan-Kettering Cancer Center; Argonne National Laboratory; U.S. Department of Energy","keywords":"Epigenetics; Biology; Cancer cell; Cell; Cell biology; Carcinogenesis; Metastasis; Cancer research; Cancer; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001852627,0.000538333,0.0005368861,0.00009774435,0.00005154641,0.00004156685,0.0004873671,0.0009585519,0.00002989447],"category_scores_gemma":[0.00004794164,0.0005994351,0.0002363506,0.0001986287,0.0001442277,0.000008870388,0.0006297299,0.0004058511,0.00001241774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003360136,"about_ca_system_score_gemma":0.001163774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845377,"about_ca_topic_score_gemma":0.00001691068,"domain_scores_codex":[0.9973652,0.00009478516,0.0005835133,0.001124888,0.0003571279,0.0004745306],"domain_scores_gemma":[0.9976403,0.00001731722,0.0006032976,0.001023221,0.0005077973,0.0002080619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001317997,0.000124663,0.004086727,0.0006845969,0.0001514012,0.000002146692,0.000005579075,0.005637723,0.988842,0.000003991634,0.0003215586,0.000007836443],"study_design_scores_gemma":[0.0006890334,0.00005226092,0.02457457,0.0004298514,0.0001377677,3.199165e-8,0.000001639776,0.0007630649,0.9721572,2.825971e-7,0.0005816649,0.0006126158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925734,0.00272518,0.00204207,0.00006592692,0.00090554,0.0008950297,0.0007287124,0.00005172003,0.00001237362],"genre_scores_gemma":[0.996485,0.001527566,0.0009684917,0.00007898035,0.0006354176,0.0001521236,0.000006352737,0.000137439,0.000008613488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02048784,"threshold_uncertainty_score":0.9996457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007733998734041452,"score_gpt":0.2076296557672861,"score_spread":0.1998956570332446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}