{"id":"W3030320535","doi":"10.1101/591164","title":"A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Western Economic Diversification Canada; Wellcome Trust; National Cancer Institute; National Research Council Canada; Beijing Municipal Administration of Hospitals; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Susan G. Komen for the Cure; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Memorial Sloan-Kettering Cancer Center; Argonne National Laboratory; U.S. Department of Energy","keywords":"Epigenetics; Biology; Cancer cell; Cell; Cell biology; Carcinogenesis; Metastasis; Cancer research; Cancer; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001016043,0.0002152133,0.0001733516,0.0001172178,0.0001367702,0.0001601882,0.0001563631,0.000240184,0.002708974],"category_scores_gemma":[0.00006130079,0.00009821284,0.000145235,0.0001115897,0.0002094078,0.00008888017,0.0001307967,0.0004774534,0.0004227262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004200301,"about_ca_system_score_gemma":0.000208218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009069477,"about_ca_topic_score_gemma":0.001282767,"domain_scores_codex":[0.9999371,0.000006159512,0.000002038638,0.00001798063,0.00001846178,0.00001826137],"domain_scores_gemma":[0.99997,0.000006387559,0.000008065611,0.000003921534,0.00000400971,0.000007628921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004678212,0.000009525216,0.00007524766,0.00002499493,0.00000272991,0.00001611716,0.000004113434,0.0001086262,0.9983367,0.0001842491,0.0001280481,0.001062824],"study_design_scores_gemma":[0.000003972181,0.00003403452,0.0003367048,7.966082e-7,0.000002356754,0.0000193823,0.000003588293,0.0003769576,0.99799,0.00002177362,0.001208876,0.000001464582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777094,0.0019419,0.01074471,0.0004549331,0.0001010797,0.00005097928,0.001391578,0.0004953166,0.007109975],"genre_scores_gemma":[0.9875675,0.0005520727,0.004635624,0.0001651355,0.000008799615,0.00003876645,0.0004754585,0.00005168655,0.006504954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002708974,"threshold_uncertainty_score":0.009062409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007733998734041452,"score_gpt":0.2076296557672861,"score_spread":0.1998956570332446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}