{"id":"W3030479973","doi":"10.1200/jco.2020.38.15_suppl.3501","title":"Phase I/II study of avadomide (CC-122) in combination with R-CHOP for newly diagnosed DLBCL.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Internal medicine; Diffuse large B-cell lymphoma; Tolerability; CHOP; Pegfilgrastim; Phases of clinical research; Oncology; Gastroenterology; International Prognostic Index; Lymphoma; Surgery; Neutropenia; Clinical trial; Febrile neutropenia; Adverse effect; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053375,0.001272787,0.001080172,0.0003624805,0.0002853095,0.0008296544,0.0008971512,0.0008881057,0.003509025],"category_scores_gemma":[0.0005504765,0.0005221803,0.0005964325,0.0003239648,0.0004869762,0.0004843027,0.0002731094,0.002144574,0.000845206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009993745,"about_ca_system_score_gemma":0.001490907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002020956,"about_ca_topic_score_gemma":0.005095013,"domain_scores_codex":[0.9997572,0.0001076824,0.00001133005,0.0000426753,0.00003368382,0.00004739238],"domain_scores_gemma":[0.999597,0.0000355538,0.00006078527,0.0000288815,0.00003746558,0.0002403811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4954759,0.1766356,0.01026387,0.001567643,0.002070491,0.0006896226,0.000421342,0.003540271,0.1445194,0.0006034171,0.0119638,0.1522486],"study_design_scores_gemma":[0.5748858,0.3995073,0.01123425,0.00005691838,0.0004144875,0.0005269059,0.00005252726,0.001725222,0.005791755,0.0001367638,0.005640667,0.00002730263],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847875,0.002915113,0.0007048446,0.0004490476,0.0001395325,0.005869103,0.002122677,0.0001620479,0.002850112],"genre_scores_gemma":[0.9826295,0.002621232,0.002385562,0.0008289722,0.0001280012,0.003194521,0.004411914,0.00003568281,0.003764654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003509025,"threshold_uncertainty_score":0.01173884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08757691204413236,"score_gpt":0.4360347932947617,"score_spread":0.3484578812506294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}