{"id":"W3030491451","doi":"10.1016/j.chembiol.2020.05.007","title":"Structural Basis for the Binding Selectivity of Human CDY Chromodomains","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Pfizer; Natural Sciences and Engineering Research Council of Canada; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ministère de l’Éducation, Gouvernement de l’Ontario; Takeda Canada; University of North Carolina Wilmington; Innovative Medicines Initiative; Merck KGaA; Central China Normal University; University of Toronto; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China; Novartis Pharma; Argonne National Laboratory; Ontario Genomics Institute; Wellcome Trust; Genome Canada; University of North Carolina at Chapel Hill; Meso Scale Diagnostics; Janssen Pharmaceuticals; Boehringer Ingelheim","keywords":"Chromodomain; Histone; Lysine; Histone H3; Epigenetics; Motif (music); Chemistry; Structural motif; Cell biology; Biology; Computational biology; Biochemistry; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007047539,0.0000979525,0.0001302617,0.000009784525,0.00007151355,0.000004784263,0.0001997299,0.0001528926,0.00003198495],"category_scores_gemma":[0.0002055916,0.00006964212,0.000102755,0.00006722079,0.0001504656,0.00000158732,0.00009018515,0.00007856442,0.000002152742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008505474,"about_ca_system_score_gemma":0.00002520309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005079583,"about_ca_topic_score_gemma":0.000001281852,"domain_scores_codex":[0.9993795,0.00003228342,0.0001511435,0.0002412924,0.00003466545,0.0001611051],"domain_scores_gemma":[0.9996285,0.00005261575,0.00007978737,0.0001409283,0.00004327961,0.00005488343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003956866,0.00001006891,0.0005818611,0.00001738743,0.00001918909,5.85801e-8,0.00002441043,9.401039e-7,0.9975736,0.0002108053,0.001127524,0.0003946146],"study_design_scores_gemma":[0.0003264252,0.000239832,0.0000647587,0.000001553654,0.0000119657,9.703131e-7,0.00002410807,0.00009418203,0.9943078,0.0001017867,0.004737837,0.00008875598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99764,0.0002002084,0.001011624,0.0004716917,0.0000580068,0.0002075695,0.00004758389,0.000009809646,0.0003534661],"genre_scores_gemma":[0.9988464,0.00001104019,0.0003218805,0.0003066073,0.0003043572,0.00002215682,0.0001415663,0.000009990321,0.00003596032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003610313,"threshold_uncertainty_score":0.2839923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068651001535768,"score_gpt":0.2631541366121505,"score_spread":0.2424676265967929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}