{"id":"W3030491451","doi":"10.1016/j.chembiol.2020.05.007","title":"Structural Basis for the Binding Selectivity of Human CDY Chromodomains","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Pfizer; Natural Sciences and Engineering Research Council of Canada; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ministère de l’Éducation, Gouvernement de l’Ontario; Takeda Canada; University of North Carolina Wilmington; Innovative Medicines Initiative; Merck KGaA; Central China Normal University; University of Toronto; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China; Novartis Pharma; Argonne National Laboratory; Ontario Genomics Institute; Wellcome Trust; Genome Canada; University of North Carolina at Chapel Hill; Meso Scale Diagnostics; Janssen Pharmaceuticals; Boehringer Ingelheim","keywords":"Chromodomain; Histone; Lysine; Histone H3; Epigenetics; Motif (music); Chemistry; Structural motif; Cell biology; Biology; Computational biology; Biochemistry; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056532,0.0001923276,0.0002898003,0.000139596,0.0002882481,0.0003774074,0.0003341094,0.0003873245,0.002762951],"category_scores_gemma":[0.0002773294,0.0001645326,0.0002185715,0.00008284245,0.0002450646,0.0001685065,0.0001915662,0.0005546702,0.0007142546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000522603,"about_ca_system_score_gemma":0.0003153335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143807,"about_ca_topic_score_gemma":0.001098141,"domain_scores_codex":[0.9998548,0.00002448278,0.00001035216,0.00003507096,0.00003546785,0.00003976305],"domain_scores_gemma":[0.9998066,0.00006417271,0.00002844452,0.00001647408,0.00002407223,0.00006021533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003726362,0.00003087508,0.0006770825,0.00003044049,0.000007993852,0.0001826207,0.00002210668,0.0005191896,0.9941347,0.001947038,0.0001526997,0.001922737],"study_design_scores_gemma":[0.00006582858,0.0001816667,0.006493201,0.000005203485,0.0000139424,0.0009492972,0.00003484566,0.005424153,0.9828676,0.0005278822,0.003424148,0.00001224786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874297,0.000678073,0.008133148,0.0002573753,0.00004511857,0.00003287242,0.0002066111,0.0001041186,0.003112992],"genre_scores_gemma":[0.9969496,0.0001281438,0.001718293,0.000124538,0.000008342062,0.000008730525,0.0001309007,0.000007995017,0.0009234152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002762951,"threshold_uncertainty_score":0.009242952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068651001535768,"score_gpt":0.2631541366121505,"score_spread":0.2424676265967929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}