{"id":"W3030499850","doi":"10.1101/2020.05.28.119941","title":"An anti-CRISPR protein induces strong non-specific DNA binding activity in a CRISPR-Cas complex","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CRISPR; DNA; Nucleic acid; Cleave; RNA; Biology; Computational biology; Genome editing; Function (biology); Genetics; Guide RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274361,0.0003230556,0.0002106634,0.0002641676,0.0001463227,0.0003676612,0.0002918697,0.0003083731,0.001531992],"category_scores_gemma":[0.000201602,0.0001919387,0.0003032774,0.0001236417,0.0002415898,0.0001087704,0.0003493612,0.0006896411,0.0005583416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004528948,"about_ca_system_score_gemma":0.0001585719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004638649,"about_ca_topic_score_gemma":0.0006532453,"domain_scores_codex":[0.9996357,0.00005134751,0.00003658913,0.00007247529,0.0001357953,0.0000680645],"domain_scores_gemma":[0.9997551,0.0000466594,0.0000538825,0.00004805814,0.00002952774,0.00006677636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002623421,0.00001638183,0.00007443519,0.000006994163,0.000002467882,0.00002259424,0.000002114441,0.00002730083,0.9995493,0.00005897785,0.00002290653,0.0001901778],"study_design_scores_gemma":[0.000006269504,0.00006100759,0.001292536,0.000001660065,0.000003543814,0.0001285098,0.000003820141,0.0006888899,0.9966975,0.00002741331,0.001086861,0.000001945642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890139,0.0004144885,0.007348272,0.0001022983,0.0000502021,0.0000369853,0.0003415451,0.0001809498,0.002511407],"genre_scores_gemma":[0.9899649,0.0001001183,0.004986603,0.00008114668,0.00001040053,0.00002316057,0.0008411655,0.00006142681,0.003931174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531992,"threshold_uncertainty_score":0.005124986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02420738798667988,"score_gpt":0.2825219379461828,"score_spread":0.2583145499595029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}