{"id":"W3030535343","doi":"10.1016/j.blre.2020.100710","title":"Germline genetic factors in the pathogenesis of myeloproliferative neoplasms","year":2020,"lang":"en","type":"review","venue":"Blood Reviews","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Agence Nationale de la Recherche; MPN Research Foundation; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Germline; Biology; Genetics; Myeloproliferative neoplasm; Allele; Germline mutation; Penetrance; Disease; Phenotype; Myeloid; Population; Mutation; Gene; Cancer research; Myelofibrosis; Immunology; Medicine; Bone marrow; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005492453,0.001017828,0.006488516,0.0002428138,0.0000733159,0.00003040615,0.0004215087,0.0003534838,0.0002357793],"category_scores_gemma":[0.0005457765,0.0004898074,0.001654779,0.0010982,0.00009952427,0.0000374765,0.00009554,0.0006200125,0.0001649567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008288795,"about_ca_system_score_gemma":0.0005544486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000214562,"about_ca_topic_score_gemma":0.00003375791,"domain_scores_codex":[0.9946141,0.001251231,0.00235193,0.0008435504,0.0005197327,0.0004194392],"domain_scores_gemma":[0.9969738,0.0006504741,0.00111101,0.0009550424,0.0001004581,0.0002092249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001378037,0.001140332,0.003014616,0.03081865,0.0007414705,0.0004653054,0.0009652807,1.303599e-7,0.000003514754,0.0001242772,0.0005743197,0.9621383],"study_design_scores_gemma":[0.0008045922,0.0006489072,0.001895846,0.01973252,0.007546376,0.0003076623,0.0000421715,0.000001194118,0.00002978557,0.000006054104,0.9686057,0.0003791822],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005390526,0.9913946,0.000004909946,0.0001723017,0.0001143687,0.00719677,0.0001680273,0.00002183474,0.0003881771],"genre_scores_gemma":[0.00008801217,0.9954772,0.001257639,0.0003392265,0.0003086949,0.002036038,0.0003202059,0.00008907996,0.00008391963],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9680314,"threshold_uncertainty_score":0.9997554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08513582315563431,"score_gpt":0.3524276194796198,"score_spread":0.2672917963239855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}