{"id":"W3030546965","doi":"10.3389/fnmol.2020.00078","title":"Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis","year":2020,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Fondation Brain Canada; ALS Society of Canada","keywords":"RNA-binding protein; Amyotrophic lateral sclerosis; TARDBP; Biology; Neurodegeneration; RNA splicing; Stress granule; Translation (biology); RNA; Ribonucleoprotein; Neuroscience; Genetics; Gene; Cell biology; SOD1; Messenger RNA; Disease; Medicine; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325703,0.0001541432,0.0003456673,0.0003299093,0.00003822045,0.00002829958,0.000301766,0.00007733241,0.00001343504],"category_scores_gemma":[0.0003194278,0.000147038,0.00006109464,0.001541797,0.0002667579,0.0001966956,0.0001379494,0.0003691627,0.000004197097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001259489,"about_ca_system_score_gemma":0.0001000966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005012701,"about_ca_topic_score_gemma":0.000001579519,"domain_scores_codex":[0.9977751,0.0001294604,0.0003992247,0.0005300912,0.0007188107,0.000447262],"domain_scores_gemma":[0.9994026,0.000008534198,0.00009436942,0.0002596831,0.00004055033,0.0001942539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001271623,0.00006660174,0.08223028,0.0000497255,0.000001976931,0.0001462194,0.0001633429,0.001025498,0.9147128,0.00003128284,0.0001585372,0.00128659],"study_design_scores_gemma":[0.001932969,0.0006203055,0.8091973,0.0002783393,0.000009584342,0.000007903204,0.00003170578,0.06978918,0.1175568,0.0001097786,0.0002379083,0.0002281778],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861172,0.00007770646,0.008561268,0.004218685,0.0001703673,0.0007126413,0.00000499776,0.00002732244,0.000109826],"genre_scores_gemma":[0.991169,0.0000589182,0.007136483,0.001536403,0.00001631928,0.00002727795,0.000004970537,0.00002389587,0.00002674222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.797156,"threshold_uncertainty_score":0.5996035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03685875090263237,"score_gpt":0.2660710775379146,"score_spread":0.2292123266352822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}